DegronMD - Q8N3L3(TXLNB)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S569N	TCGA-86-8073	LUAD	TCGA	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.1944
p.S569N	DO23624	LUAD	ICGC	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.1944
p.Q222K	TCGA-86-8073	LUAD	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	210:218	Mutation rewiring degron network	0.2222
p.Q222K	DO23624	LUAD	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	210:218	Mutation rewiring degron network	0.2222
p.L217M	TCGA-A5-A0G2	UCEC	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	210:218	Mutation altering degron motif	0.5999
p.L217M	DO41235	UCEC	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	210:218	Mutation altering degron motif	0.5999
p.A210T	TCGA-BR-4201	STAD	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	210:218	Mutation altering degron motif	0.6028
p.A210T	TCGA-EC-A24G	UCEC	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	210:218	Mutation altering degron motif	0.6028
p.A210T	DO228138	PBCA	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	210:218	Mutation altering degron motif	0.6028
p.A210T	DO38707	STAD	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	210:218	Mutation altering degron motif	0.6028
p.A210T	DO40996	UCEC	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	210:218	Mutation altering degron motif	0.6028
p.G567R	TCGA-DA-A95Z	SKCM	TCGA	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.25
p.G567R	DO219481	SKCM	ICGC	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.25
p.R550Q	TCGA-DM-A0X9	COAD	TCGA	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.1389
p.R550Q	TCGA-EE-A29D	SKCM	TCGA	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.1389
p.R550Q	DO8618	COAD	ICGC	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.1389
p.R550Q	DO38123	SKCM	ICGC	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.1389
p.E572K	TCGA-EE-A2MR	SKCM	TCGA	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.1111
p.E572K	DO37819	SKCM	ICGC	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.1111
p.E572K	SIDM00284	Melanoma	GDSC	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.1111
p.E572K	ACH-000805	Skin Cancer	CCLE	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.1111
p.E572K	COLO-679	skin	COSMIC	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.1111
p.R211Q	TCGA-ER-A19T	SKCM	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	210:218	Mutation altering degron motif	0.7329
p.R211Q	DO51251	SKCM	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	210:218	Mutation altering degron motif	0.7329
p.A565V	TCGA-IB-7651	PAAD	TCGA	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.3056
p.A565V	DO46657	PAAD	ICGC	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.3056
p.R211G	DO222566	BTCA	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	210:218	Mutation altering degron motif	0.7568
p.P548S	DO222569	BTCA	ICGC	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.0833
p.R550W	DO233759	GACA	ICGC	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.1389
p.R550W	DO233871	GACA	ICGC	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.1389
p.R550W	SIDM01729	Endometrial Carcinoma	GDSC	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.1389
p.R550W	ACH-000909	Endometrial/Uterine Cancer	CCLE	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.1389
p.H224N	DO228978	LICA	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	210:218	Mutation rewiring degron network	0.1667
p.I208T	DO27853	MALY	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	210:218	Mutation rewiring degron network	0.2778
p.A207T	DO228465	MALY	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	210:218	Mutation rewiring degron network	0.25
p.P574L	DO222653	MELA	ICGC	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.0556
p.P574L	DO229459	SKCA	ICGC	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.0556
p.P574L	SIDM00081	Melanoma	GDSC	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.0556
p.P574L	ACH-000615	Skin Cancer	CCLE	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.0556
p.P574L	SK-MEL-28	skin	COSMIC	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.0556
p.L217P	DO229253	THCA	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	210:218	Mutation altering degron motif	0.7582
p.A571T	SIDM00855	Other Sarcomas	GDSC	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.1389
p.E566K	SIDM00281	Other Solid Cancers	GDSC	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.2778
p.E566K	DJM-1	skin	COSMIC	PPLTPQAE	DEG_SCF_FBW7_2	557:564	Mutation rewiring degron network	0.2778
p.S216R	SIDM00282	Colorectal Carcinoma	GDSC	ARSKLESLC	DEG_APCC_DBOX_1	210:218	Mutation altering degron motif	0.7427
p.S216R	ACH-000998	Colon/Colorectal Cancer	CCLE	ARSKLESLC	DEG_APCC_DBOX_1	210:218	Mutation altering degron motif	0.7427
p.S216R	CW-2	large intestine	COSMIC	ARSKLESLC	DEG_APCC_DBOX_1	210:218	Mutation altering degron motif	0.7427
p.R219W	SIDM01322	Oral Cavity Carcinoma	GDSC	ARSKLESLC	DEG_APCC_DBOX_1	210:218	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TXLNB

UniProt ID: Q8N3L3

Entrez ID: 167838

Protein name: Beta-taxilin (Muscle-derived protein 77) (hMDP77)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TXLNB in