DegronMD

Uniprot ID: Q8N3L3

Source protein: Beta-taxilin

Source gene: TXLNB

Class: DEG_APCC_DBOX_1

Location: 210:218

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6533

ASA_SCORE: 74.0556

COIL: 0.0502

CONS_SCORE: 0.6689

DSS_SCORE: 0.3491

HELIX: 0.9508

FCONS_SCORE: 1.2482

RIG_SCORE: 0.742

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q222K	TCGA-86-8073	LUAD	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	0.2222
p.Q222K	DO23624	LUAD	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	0.2222
p.L217M	TCGA-A5-A0G2	UCEC	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	0.5999
p.L217M	DO41235	UCEC	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	0.5999
p.A210T	TCGA-BR-4201	STAD	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	0.6028
p.A210T	TCGA-EC-A24G	UCEC	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	0.6028
p.A210T	DO228138	PBCA	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	0.6028
p.A210T	DO38707	STAD	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	0.6028
p.A210T	DO40996	UCEC	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	0.6028
p.R211Q	TCGA-ER-A19T	SKCM	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	0.7329
p.R211Q	DO51251	SKCM	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	0.7329
p.R211G	DO222566	BTCA	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	0.7568
p.H224N	DO228978	LICA	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	0.1667
p.I208T	DO27853	MALY	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	0.2778
p.A207T	DO228465	MALY	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	0.25
p.L217P	DO229253	THCA	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	0.7582
p.S216R	SIDM00282	Colorectal Carcinoma	GDSC	ARSKLESLC	DEG_APCC_DBOX_1	0.7427
p.S216R	ACH-000998	Colon/Colorectal Cancer	CCLE	ARSKLESLC	DEG_APCC_DBOX_1	0.7427
p.S216R	CW-2	large_intestine	COSMIC	ARSKLESLC	DEG_APCC_DBOX_1	0.7427
p.R219W	SIDM01322	Oral Cavity Carcinoma	GDSC	ARSKLESLC	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons