DegronMD

Uniprot ID: Q9NUQ3

Source protein: Gamma-taxilin

Source gene: TXLNG

Class: DEG_APCC_DBOX_1

Location: 204:212

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5353

ASA_SCORE: 64.6444

COIL: 0.0313

CONS_SCORE: 0.6881

DSS_SCORE: 0.3646

HELIX: 0.9683

FCONS_SCORE: 1.2935

RIG_SCORE: 0.7478

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L194M	TCGA-56-8504	LUSC	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	0.0556
p.A204V	TCGA-E7-A97P	BLCA	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	0.5825
p.R217G	TCGA-ZF-A9RC	BLCA	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	0.1944
p.E203D	DO8127	COAD	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	0.3056
p.E209K	DO11854	GBM	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	0.591
p.H206R	DO45039	LINC	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	0.8244
p.A201V	DO41871	UCEC	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	0.25
p.T202K	EFM-192A	breast	COSMIC	ARSKLESLC	DEG_APCC_DBOX_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons