DegronMD

Uniprot ID: Q8N3L3

Source protein: Beta-taxilin

Source gene: TXLNB

Class: DEG_SCF_FBW7_2

Location: 557:564

E3 ligase: FBXW7

DEGRON score: 0.9924

ASA_SCORE: 92.9

COIL: 0.8594

CONS_SCORE: 0.2862

DSS_SCORE: 0.8788

HELIX: 0.1355

FCONS_SCORE: 1.0567

RIG_SCORE: 0.5811

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S569N	TCGA-86-8073	LUAD	TCGA	PPLTPQAE	DEG_SCF_FBW7_2	0.1944
p.S569N	DO23624	LUAD	ICGC	PPLTPQAE	DEG_SCF_FBW7_2	0.1944
p.G567R	TCGA-DA-A95Z	SKCM	TCGA	PPLTPQAE	DEG_SCF_FBW7_2	0.25
p.G567R	DO219481	SKCM	ICGC	PPLTPQAE	DEG_SCF_FBW7_2	0.25
p.R550Q	TCGA-DM-A0X9	COAD	TCGA	PPLTPQAE	DEG_SCF_FBW7_2	0.1389
p.R550Q	TCGA-EE-A29D	SKCM	TCGA	PPLTPQAE	DEG_SCF_FBW7_2	0.1389
p.R550Q	DO8618	COAD	ICGC	PPLTPQAE	DEG_SCF_FBW7_2	0.1389
p.R550Q	DO38123	SKCM	ICGC	PPLTPQAE	DEG_SCF_FBW7_2	0.1389
p.E572K	TCGA-EE-A2MR	SKCM	TCGA	PPLTPQAE	DEG_SCF_FBW7_2	0.1111
p.E572K	DO37819	SKCM	ICGC	PPLTPQAE	DEG_SCF_FBW7_2	0.1111
p.E572K	SIDM00284	Melanoma	GDSC	PPLTPQAE	DEG_SCF_FBW7_2	0.1111
p.E572K	ACH-000805	Skin Cancer	CCLE	PPLTPQAE	DEG_SCF_FBW7_2	0.1111
p.E572K	COLO-679	skin	COSMIC	PPLTPQAE	DEG_SCF_FBW7_2	0.1111
p.A565V	TCGA-IB-7651	PAAD	TCGA	PPLTPQAE	DEG_SCF_FBW7_2	0.3056
p.A565V	DO46657	PAAD	ICGC	PPLTPQAE	DEG_SCF_FBW7_2	0.3056
p.P548S	DO222569	BTCA	ICGC	PPLTPQAE	DEG_SCF_FBW7_2	0.0833
p.R550W	DO233759	GACA	ICGC	PPLTPQAE	DEG_SCF_FBW7_2	0.1389
p.R550W	DO233871	GACA	ICGC	PPLTPQAE	DEG_SCF_FBW7_2	0.1389
p.R550W	SIDM01729	Endometrial Carcinoma	GDSC	PPLTPQAE	DEG_SCF_FBW7_2	0.1389
p.R550W	ACH-000909	Endometrial/Uterine Cancer	CCLE	PPLTPQAE	DEG_SCF_FBW7_2	0.1389
p.P574L	DO222653	MELA	ICGC	PPLTPQAE	DEG_SCF_FBW7_2	0.0556
p.P574L	DO229459	SKCA	ICGC	PPLTPQAE	DEG_SCF_FBW7_2	0.0556
p.P574L	SIDM00081	Melanoma	GDSC	PPLTPQAE	DEG_SCF_FBW7_2	0.0556
p.P574L	ACH-000615	Skin Cancer	CCLE	PPLTPQAE	DEG_SCF_FBW7_2	0.0556
p.P574L	SK-MEL-28	skin	COSMIC	PPLTPQAE	DEG_SCF_FBW7_2	0.0556
p.A571T	SIDM00855	Other Sarcomas	GDSC	PPLTPQAE	DEG_SCF_FBW7_2	0.1389
p.E566K	SIDM00281	Other Solid Cancers	GDSC	PPLTPQAE	DEG_SCF_FBW7_2	0.2778
p.E566K	DJM-1	skin	COSMIC	PPLTPQAE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3L3	Beta-taxilin	DEG_SCF_FBW7_2	557:564	PPLTPQAE	FBXW7	0.9924	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPLTPQAE

Degron related mutations and impact score

Drug responses associated with TXLNB mutations

All proteins holding degron of PPLTPQAE