DegronMD - P40763(STAT3)

GO - Biological processes (BP): astrocyte differentiation [GO:0048708]; cell population proliferation [GO:0008283]; cellular response to hormone stimulus [GO:0032870]; cellular response to leptin stimulus [GO:0044320]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; eating behavior [GO:0042755]; energy homeostasis [GO:0097009]; eye photoreceptor cell differentiation [GO:0001754]; glucose homeostasis [GO:0042593]; growth hormone receptor signaling pathway [GO:0060396]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; inflammatory response [GO:0006954]; interleukin-6-mediated signaling pathway [GO:0070102]; intracellular receptor signaling pathway [GO:0030522]; leptin-mediated signaling pathway [GO:0033210]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of autophagy [GO:0010507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of glycolytic process [GO:0045820]; negative regulation of neuron migration [GO:2001223]; negative regulation of primary miRNA processing [GO:2000635]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; phosphorylation [GO:0016310]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of gene silencing by miRNA [GO:2000637]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of metalloendopeptidase activity [GO:1904685]; positive regulation of miRNA-mediated gene silencing by inhibition of translation [GO:1905618]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; protein import into nucleus [GO:0006606]; radial glial cell differentiation [GO:0060019]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of feeding behavior [GO:0060259]; regulation of multicellular organism growth [GO:0040014]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estradiol [GO:0032355]; response to leptin [GO:0044321]; response to peptide hormone [GO:0043434]; sexual reproduction [GO:0019953]; signal transduction [GO:0007165]; stem cell population maintenance [GO:0019827]; temperature homeostasis [GO:0001659]; T-helper 17 cell lineage commitment [GO:0072540]; T-helper 17 type immune response [GO:0072538]; transforming growth factor beta receptor signaling pathway [GO:0007179] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y686D	TCGA-AX-A2HC	UCEC	TCGA	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation blocking phosphorylation signal	0.5
p.Y686D	DO41572	UCEC	ICGC	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation blocking phosphorylation signal	0.5
p.P675S	TCGA-B5-A0JY	UCEC	TCGA	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation altering degron motif	0.5641
p.P675S	DO43041	UCEC	ICGC	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation altering degron motif	0.5641
p.D661V	TCGA-BA-5151	HNSC	TCGA	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation rewiring degron network	0.0556
p.D661V	TCGA-FA-A6HN	DLBC	TCGA	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation rewiring degron network	0.0556
p.D661V	DO219887	DLBC	ICGC	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation rewiring degron network	0.0556
p.D661V	DO14276	HNSC	ICGC	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation rewiring degron network	0.0556
p.D661Y	TCGA-CG-4465	STAD	TCGA	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation rewiring degron network	0.0556
p.D661Y	TCGA-VS-AA62	CESC	TCGA	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation rewiring degron network	0.0556
p.D661Y	DO219745	CESC	ICGC	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation rewiring degron network	0.0556
p.D661Y	DO229137	NKTL	ICGC	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation rewiring degron network	0.0556
p.D661Y	DO38627	STAD	ICGC	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation rewiring degron network	0.0556
p.D661Y	SIDM00845	Burkitt's Lymphoma	GDSC	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation rewiring degron network	0.0556
p.D661Y	SIDM01064	Hodgkin's Lymphoma	GDSC	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation rewiring degron network	0.0556
p.D661Y	ACH-000267	Lymphoma	CCLE	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation rewiring degron network	0.0556
p.D661Y	HDLM-2	haematopoietic and lymphoid tissue	COSMIC	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation rewiring degron network	0.0556
p.A682T	TCGA-EO-A22U	UCEC	TCGA	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation rewiring degron network	0.1667
p.A682T	DO43755	UCEC	ICGC	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation rewiring degron network	0.1667
p.K679N	TCGA-FI-A2D5	UCEC	TCGA	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation blocking ubiquitination signal	0.6944
p.K679N	DO41331	UCEC	ICGC	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation blocking ubiquitination signal	0.6944
p.P678L	TCGA-W3-AA1V	SKCM	TCGA	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation rewiring degron network	0.2778
p.P678L	DO51276	SKCM	ICGC	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation rewiring degron network	0.2778
p.P678S	TCGA-W3-AA1V	SKCM	TCGA	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation rewiring degron network	0.2778
p.P678S	DO51276	SKCM	ICGC	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation rewiring degron network	0.2778
p.I665V	DO228221	MALY	ICGC	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation rewiring degron network	0.1667
p.V667L	DO52674	MALY	ICGC	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation rewiring degron network	0.2222
p.S668F	DO50420	PRAD	ICGC	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation rewiring degron network	0.25
p.Y672C	SIDM00479	Esophageal Carcinoma	GDSC	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation altering degron motif	0.5976
p.Y672C	ACH-000679	Esophageal Cancer	CCLE	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation altering degron motif	0.5976
p.Y672C	OE19	oesophagus	COSMIC	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation altering degron motif	0.5976
p.D676A	SIDM01611	Endometrial Carcinoma	GDSC	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation altering degron motif	0.7793
p.D676A	ACH-000996	Endometrial/Uterine Cancer	CCLE	VYLYPD	LIG_APCC_ABBA_1	671:676	Mutation altering degron motif	0.7793

Kaplan plot for STAT3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STAT3

UniProt ID: P40763

Entrez ID: 6774

Protein name: Signal transducer and activator of transcription 3 (Acute-phase response factor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STAT3 in