DegronMD

Uniprot ID: P40763

Source protein: Signal transducer and activator of transcription 3

Source gene: STAT3

Class: LIG_APCC_ABBA_1

Location: 671:676

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8542

ASA_SCORE: 50.2167

COIL: 0.5742

CONS_SCORE: 0.5818

DSS_SCORE: 0.0999

HELIX: 0.0547

FCONS_SCORE: 1.2373

RIG_SCORE: 0.8826

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y686D	TCGA-AX-A2HC	UCEC	TCGA	VYLYPD	LIG_APCC_ABBA_1	0.5
p.Y686D	DO41572	UCEC	ICGC	VYLYPD	LIG_APCC_ABBA_1	0.5
p.P675S	TCGA-B5-A0JY	UCEC	TCGA	VYLYPD	LIG_APCC_ABBA_1	0.5641
p.P675S	DO43041	UCEC	ICGC	VYLYPD	LIG_APCC_ABBA_1	0.5641
p.D661V	TCGA-BA-5151	HNSC	TCGA	VYLYPD	LIG_APCC_ABBA_1	0.0556
p.D661V	TCGA-FA-A6HN	DLBC	TCGA	VYLYPD	LIG_APCC_ABBA_1	0.0556
p.D661V	DO219887	DLBC	ICGC	VYLYPD	LIG_APCC_ABBA_1	0.0556
p.D661V	DO14276	HNSC	ICGC	VYLYPD	LIG_APCC_ABBA_1	0.0556
p.D661Y	TCGA-CG-4465	STAD	TCGA	VYLYPD	LIG_APCC_ABBA_1	0.0556
p.D661Y	TCGA-VS-AA62	CESC	TCGA	VYLYPD	LIG_APCC_ABBA_1	0.0556
p.D661Y	DO219745	CESC	ICGC	VYLYPD	LIG_APCC_ABBA_1	0.0556
p.D661Y	DO229137	NKTL	ICGC	VYLYPD	LIG_APCC_ABBA_1	0.0556
p.D661Y	DO38627	STAD	ICGC	VYLYPD	LIG_APCC_ABBA_1	0.0556
p.D661Y	SIDM00845	Burkitt's Lymphoma	GDSC	VYLYPD	LIG_APCC_ABBA_1	0.0556
p.D661Y	SIDM01064	Hodgkin's Lymphoma	GDSC	VYLYPD	LIG_APCC_ABBA_1	0.0556
p.D661Y	ACH-000267	Lymphoma	CCLE	VYLYPD	LIG_APCC_ABBA_1	0.0556
p.D661Y	HDLM-2	haematopoietic_and_lymphoid_tissue	COSMIC	VYLYPD	LIG_APCC_ABBA_1	0.0556
p.A682T	TCGA-EO-A22U	UCEC	TCGA	VYLYPD	LIG_APCC_ABBA_1	0.1667
p.A682T	DO43755	UCEC	ICGC	VYLYPD	LIG_APCC_ABBA_1	0.1667
p.K679N	TCGA-FI-A2D5	UCEC	TCGA	VYLYPD	LIG_APCC_ABBA_1	0.6944
p.K679N	DO41331	UCEC	ICGC	VYLYPD	LIG_APCC_ABBA_1	0.6944
p.P678L	TCGA-W3-AA1V	SKCM	TCGA	VYLYPD	LIG_APCC_ABBA_1	0.2778
p.P678L	DO51276	SKCM	ICGC	VYLYPD	LIG_APCC_ABBA_1	0.2778
p.P678S	TCGA-W3-AA1V	SKCM	TCGA	VYLYPD	LIG_APCC_ABBA_1	0.2778
p.P678S	DO51276	SKCM	ICGC	VYLYPD	LIG_APCC_ABBA_1	0.2778
p.I665V	DO228221	MALY	ICGC	VYLYPD	LIG_APCC_ABBA_1	0.1667
p.V667L	DO52674	MALY	ICGC	VYLYPD	LIG_APCC_ABBA_1	0.2222
p.S668F	DO50420	PRAD	ICGC	VYLYPD	LIG_APCC_ABBA_1	0.25
p.Y672C	SIDM00479	Esophageal Carcinoma	GDSC	VYLYPD	LIG_APCC_ABBA_1	0.5976
p.Y672C	ACH-000679	Esophageal Cancer	CCLE	VYLYPD	LIG_APCC_ABBA_1	0.5976
p.Y672C	OE19	oesophagus	COSMIC	VYLYPD	LIG_APCC_ABBA_1	0.5976
p.D676A	SIDM01611	Endometrial Carcinoma	GDSC	VYLYPD	LIG_APCC_ABBA_1	0.7793
p.D676A	ACH-000996	Endometrial/Uterine Cancer	CCLE	VYLYPD	LIG_APCC_ABBA_1	0.7793

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VYLYPD

Degron related mutations and impact score

Drug responses associated with STAT3 mutations

All proteins holding degron of VYLYPD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40763	Signal transducer and activator of transcription 3	LIG_APCC_ABBA_1	671:676	VYLYPD	APC,CDC20,FZR1	0.8542	More...