DegronMD - P40818(USP8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K462N	TCGA-FI-A2D5	UCEC	TCGA	KARIHAE	LIG_APCC_ABBAyCdc20_2	462:468	Mutation altering degron motif	0.6918
p.K462N	DO41331	UCEC	ICGC	KARIHAE	LIG_APCC_ABBAyCdc20_2	462:468	Mutation altering degron motif	0.6918
p.E468K	TCGA-XF-AAMY	BLCA	TCGA	KARIHAE	LIG_APCC_ABBAyCdc20_2	462:468	Mutation altering degron motif	0.7022
p.E468K	DO219050	BLCA	ICGC	KARIHAE	LIG_APCC_ABBAyCdc20_2	462:468	Mutation altering degron motif	0.7022
p.E460K	DO227855	COCA	ICGC	KARIHAE	LIG_APCC_ABBAyCdc20_2	462:468	Mutation rewiring degron network	0.2778
p.R464C	DO234278	ESAD	ICGC	KARIHAE	LIG_APCC_ABBAyCdc20_2	462:468	Mutation altering degron motif	0.719
p.R464C	SIDM00122	Breast Carcinoma	GDSC	KARIHAE	LIG_APCC_ABBAyCdc20_2	462:468	Mutation altering degron motif	0.719
p.R464C	BT-549	breast	COSMIC	KARIHAE	LIG_APCC_ABBAyCdc20_2	462:468	Mutation altering degron motif	0.719
p.S452Y	SIDM00678	Bladder Carcinoma	GDSC	KARIHAE	LIG_APCC_ABBAyCdc20_2	462:468	Mutation blocking phosphorylation signal	0.5
p.S452Y	HT-1376	urinary tract	COSMIC	KARIHAE	LIG_APCC_ABBAyCdc20_2	462:468	Mutation blocking phosphorylation signal	0.5
p.M456V	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	KARIHAE	LIG_APCC_ABBAyCdc20_2	462:468	Mutation rewiring degron network	0.1667
p.M456V	HT	haematopoietic and lymphoid tissue	COSMIC	KARIHAE	LIG_APCC_ABBAyCdc20_2	462:468	Mutation rewiring degron network	0.1667
p.R467T	ACH-000345	Neuroblastoma	CCLE	KARIHAE	LIG_APCC_ABBAyCdc20_2	462:468	Mutation altering degron motif	0.7876
p.R467T	KP-N-RT-BM-1	autonomic ganglia	COSMIC	KARIHAE	LIG_APCC_ABBAyCdc20_2	462:468	Mutation altering degron motif	0.7876

Kaplan plot for USP8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP8

UniProt ID: P40818

Entrez ID: 9101

Protein name: Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USP8 in