DegronMD

Uniprot ID: P40818

Source protein: Ubiquitin carboxyl-terminal hydrolase 8

Source gene: USP8

Class: LIG_APCC_ABBAyCdc20_2

Location: 462:468

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.849

ASA_SCORE: 85.7714

COIL: 0.0347

CONS_SCORE: 0.4434

DSS_SCORE: 0.4725

HELIX: 0.9646

FCONS_SCORE: 1.0159

RIG_SCORE: 0.7838

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K462N	TCGA-FI-A2D5	UCEC	TCGA	KARIHAE	LIG_APCC_ABBAyCdc20_2	0.6918
p.K462N	DO41331	UCEC	ICGC	KARIHAE	LIG_APCC_ABBAyCdc20_2	0.6918
p.E468K	TCGA-XF-AAMY	BLCA	TCGA	KARIHAE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E468K	DO219050	BLCA	ICGC	KARIHAE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E460K	DO227855	COCA	ICGC	KARIHAE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R464C	DO234278	ESAD	ICGC	KARIHAE	LIG_APCC_ABBAyCdc20_2	0.719
p.R464C	SIDM00122	Breast Carcinoma	GDSC	KARIHAE	LIG_APCC_ABBAyCdc20_2	0.719
p.R464C	BT-549	breast	COSMIC	KARIHAE	LIG_APCC_ABBAyCdc20_2	0.719
p.S452Y	SIDM00678	Bladder Carcinoma	GDSC	KARIHAE	LIG_APCC_ABBAyCdc20_2	0.5
p.S452Y	HT-1376	urinary_tract	COSMIC	KARIHAE	LIG_APCC_ABBAyCdc20_2	0.5
p.M456V	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	KARIHAE	LIG_APCC_ABBAyCdc20_2	0.1667
p.M456V	HT	haematopoietic_and_lymphoid_tissue	COSMIC	KARIHAE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R467T	ACH-000345	Neuroblastoma	CCLE	KARIHAE	LIG_APCC_ABBAyCdc20_2	0.7876
p.R467T	KP-N-RT-BM-1	autonomic_ganglia	COSMIC	KARIHAE	LIG_APCC_ABBAyCdc20_2	0.7876

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40818	Ubiquitin carboxyl-terminal hydrolase 8	LIG_APCC_ABBAyCdc20_2	462:468	KARIHAE	APC,CDC20,FZR1	0.849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons