DegronMD - P41002(CCNF)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G583C	TCGA-BR-8382	STAD	TCGA	VTTPTAE	DEG_SCF_FBW7_2	586:592	Mutation rewiring degron network	0.25
p.G583C	DO47925	STAD	ICGC	VTTPTAE	DEG_SCF_FBW7_2	586:592	Mutation rewiring degron network	0.25
p.S595I	TCGA-DX-AB2W	SARC	TCGA	VTTPTAE	DEG_SCF_FBW7_2	586:592	Mutation rewiring degron network	0.25
p.S595I	DO229028	LICA	ICGC	VTTPTAE	DEG_SCF_FBW7_2	586:592	Mutation rewiring degron network	0.25
p.S595I	DO220095	SARC	ICGC	VTTPTAE	DEG_SCF_FBW7_2	586:592	Mutation rewiring degron network	0.25
p.Q579K	TCGA-FS-A1ZK	SKCM	TCGA	VTTPTAE	DEG_SCF_FBW7_2	586:592	Mutation rewiring degron network	0.1389
p.Q579K	DO37474	SKCM	ICGC	VTTPTAE	DEG_SCF_FBW7_2	586:592	Mutation rewiring degron network	0.1389
p.V586I	DO234401	ESAD	ICGC	VTTPTAE	DEG_SCF_FBW7_2	586:592	Mutation altering degron motif	0.5965
p.V586I	DO33091	PACA	ICGC	VTTPTAE	DEG_SCF_FBW7_2	586:592	Mutation altering degron motif	0.5965
p.G602V	DO228976	LICA	ICGC	VTTPTAE	DEG_SCF_FBW7_2	586:592	Mutation rewiring degron network	0.0556
p.A591T	SIDM01618	B-Lymphoblastic Leukemia	GDSC	VTTPTAE	DEG_SCF_FBW7_2	586:592	Mutation altering degron motif	0.6028
p.A591T	ACH-000942	Leukemia	CCLE	VTTPTAE	DEG_SCF_FBW7_2	586:592	Mutation altering degron motif	0.6028
p.S584R	ACH-001039	Colon/Colorectal Cancer	CCLE	VTTPTAE	DEG_SCF_FBW7_2	586:592	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons