DegronMD

Uniprot ID: P41002

Source protein: Cyclin-F

Source gene: CCNF

Class: DEG_SCF_FBW7_2

Location: 586:592

E3 ligase: FBXW7

DEGRON score: 0.8337

ASA_SCORE: 62.7857

COIL: 0.5906

CONS_SCORE: 0.3389

DSS_SCORE: 0.5581

HELIX: 0.288

FCONS_SCORE: 0.8814

RIG_SCORE: 0.7608

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G583C	TCGA-BR-8382	STAD	TCGA	VTTPTAE	DEG_SCF_FBW7_2	0.25
p.G583C	DO47925	STAD	ICGC	VTTPTAE	DEG_SCF_FBW7_2	0.25
p.S595I	TCGA-DX-AB2W	SARC	TCGA	VTTPTAE	DEG_SCF_FBW7_2	0.25
p.S595I	DO229028	LICA	ICGC	VTTPTAE	DEG_SCF_FBW7_2	0.25
p.S595I	DO220095	SARC	ICGC	VTTPTAE	DEG_SCF_FBW7_2	0.25
p.Q579K	TCGA-FS-A1ZK	SKCM	TCGA	VTTPTAE	DEG_SCF_FBW7_2	0.1389
p.Q579K	DO37474	SKCM	ICGC	VTTPTAE	DEG_SCF_FBW7_2	0.1389
p.V586I	DO234401	ESAD	ICGC	VTTPTAE	DEG_SCF_FBW7_2	0.5965
p.V586I	DO33091	PACA	ICGC	VTTPTAE	DEG_SCF_FBW7_2	0.5965
p.G602V	DO228976	LICA	ICGC	VTTPTAE	DEG_SCF_FBW7_2	0.0556
p.A591T	SIDM01618	B-Lymphoblastic Leukemia	GDSC	VTTPTAE	DEG_SCF_FBW7_2	0.6028
p.A591T	ACH-000942	Leukemia	CCLE	VTTPTAE	DEG_SCF_FBW7_2	0.6028
p.S584R	ACH-001039	Colon/Colorectal Cancer	CCLE	VTTPTAE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P41002	Cyclin-F	DEG_SCF_FBW7_2	586:592	VTTPTAE	FBXW7	0.8337	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons