DegronMD - P41134(ID1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P118L	TCGA-2H-A9GN	ESCA	TCGA	VRAPLSTLN	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.1389
p.P118L	TCGA-CV-5435	HNSC	TCGA	VRAPLSTLN	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.1389
p.P118L	DO14299	HNSC	ICGC	VRAPLSTLN	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.1389
p.T117I	TCGA-A5-A0GH	UCEC	TCGA	VRAPLSTLN	DEG_APCC_DBOX_1	125:133	Mutation blocking phosphorylation signal	0.5556
p.T117I	DO43634	UCEC	ICGC	VRAPLSTLN	DEG_APCC_DBOX_1	125:133	Mutation blocking phosphorylation signal	0.5556
p.T131A	TCGA-B5-A0K9	UCEC	TCGA	VRAPLSTLN	DEG_APCC_DBOX_1	125:133	Mutation altering degron motif	0.6028
p.T131A	DO42097	UCEC	ICGC	VRAPLSTLN	DEG_APCC_DBOX_1	125:133	Mutation altering degron motif	0.6028
p.G116R	TCGA-SL-A6J9	UCEC	TCGA	VRAPLSTLN	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.0833
p.G116R	DO219786	UCEC	ICGC	VRAPLSTLN	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.0833
p.R121P	TCGA-ZF-A9R7	BLCA	TCGA	VRAPLSTLN	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.2222
p.R121P	DO219064	BLCA	ICGC	VRAPLSTLN	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.2222
p.L132R	DO233260	GACA	ICGC	VRAPLSTLN	DEG_APCC_DBOX_1	125:133	Mutation altering degron motif	0.8428
p.L132I	DO48682	LIRI	ICGC	VRAPLSTLN	DEG_APCC_DBOX_1	125:133	Mutation altering degron motif	0.6063
p.P118S	DO220862	MELA	ICGC	VRAPLSTLN	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.1389
p.P128L	DO222847	MELA	ICGC	VRAPLSTLN	DEG_APCC_DBOX_1	125:133	Mutation altering degron motif	0.6471
p.A141T	SIDM00422	Hodgkin's Lymphoma	GDSC	VRAPLSTLN	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.1111
p.A141T	ACH-001203	Lymphoma	CCLE	VRAPLSTLN	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.1111
p.A141T	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	VRAPLSTLN	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.1111
p.N133H	SIDM00816	Kidney Carcinoma	GDSC	VRAPLSTLN	DEG_APCC_DBOX_1	125:133	Mutation altering degron motif	0.6312
p.N133H	ACH-002192	Kidney Cancer	CCLE	VRAPLSTLN	DEG_APCC_DBOX_1	125:133	Mutation altering degron motif	0.6312
p.N133H	RCC-MF	kidney	COSMIC	VRAPLSTLN	DEG_APCC_DBOX_1	125:133	Mutation altering degron motif	0.6312
p.E135K	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	VRAPLSTLN	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.2778
p.E135K	ACH-000416	Lung Cancer	CCLE	VRAPLSTLN	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.2778
p.E135K	NCI-H838	lung	COSMIC	VRAPLSTLN	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.2778

Kaplan plot for ID1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ID1

UniProt ID: P41134

Entrez ID: 3397

Protein name: DNA-binding protein inhibitor ID-1 (Class B basic helix-loop-helix protein 24) (bHLHb24) (Inhibitor of DNA binding 1) (Inhibitor of differentiation 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ID1 in