DegronMD

Uniprot ID: P41134

Source protein: DNA-binding protein inhibitor ID-1

Source gene: ID1

Class: DEG_APCC_DBOX_1

Location: 125:133

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9919

ASA_SCORE: 81.4444

COIL: 0.7802

CONS_SCORE: 0.4535

DSS_SCORE: 0.3651

HELIX: 0.1792

FCONS_SCORE: 1.194

RIG_SCORE: 0.741

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P118L	TCGA-2H-A9GN	ESCA	TCGA	VRAPLSTLN	DEG_APCC_DBOX_1	0.1389
p.P118L	TCGA-CV-5435	HNSC	TCGA	VRAPLSTLN	DEG_APCC_DBOX_1	0.1389
p.P118L	DO14299	HNSC	ICGC	VRAPLSTLN	DEG_APCC_DBOX_1	0.1389
p.T117I	TCGA-A5-A0GH	UCEC	TCGA	VRAPLSTLN	DEG_APCC_DBOX_1	0.5556
p.T117I	DO43634	UCEC	ICGC	VRAPLSTLN	DEG_APCC_DBOX_1	0.5556
p.T131A	TCGA-B5-A0K9	UCEC	TCGA	VRAPLSTLN	DEG_APCC_DBOX_1	0.6028
p.T131A	DO42097	UCEC	ICGC	VRAPLSTLN	DEG_APCC_DBOX_1	0.6028
p.G116R	TCGA-SL-A6J9	UCEC	TCGA	VRAPLSTLN	DEG_APCC_DBOX_1	0.0833
p.G116R	DO219786	UCEC	ICGC	VRAPLSTLN	DEG_APCC_DBOX_1	0.0833
p.R121P	TCGA-ZF-A9R7	BLCA	TCGA	VRAPLSTLN	DEG_APCC_DBOX_1	0.2222
p.R121P	DO219064	BLCA	ICGC	VRAPLSTLN	DEG_APCC_DBOX_1	0.2222
p.L132R	DO233260	GACA	ICGC	VRAPLSTLN	DEG_APCC_DBOX_1	0.8428
p.L132I	DO48682	LIRI	ICGC	VRAPLSTLN	DEG_APCC_DBOX_1	0.6063
p.P118S	DO220862	MELA	ICGC	VRAPLSTLN	DEG_APCC_DBOX_1	0.1389
p.P128L	DO222847	MELA	ICGC	VRAPLSTLN	DEG_APCC_DBOX_1	0.6471
p.A141T	SIDM00422	Hodgkin's Lymphoma	GDSC	VRAPLSTLN	DEG_APCC_DBOX_1	0.1111
p.A141T	ACH-001203	Lymphoma	CCLE	VRAPLSTLN	DEG_APCC_DBOX_1	0.1111
p.A141T	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	VRAPLSTLN	DEG_APCC_DBOX_1	0.1111
p.N133H	SIDM00816	Kidney Carcinoma	GDSC	VRAPLSTLN	DEG_APCC_DBOX_1	0.6312
p.N133H	ACH-002192	Kidney Cancer	CCLE	VRAPLSTLN	DEG_APCC_DBOX_1	0.6312
p.N133H	RCC-MF	kidney	COSMIC	VRAPLSTLN	DEG_APCC_DBOX_1	0.6312
p.E135K	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	VRAPLSTLN	DEG_APCC_DBOX_1	0.2778
p.E135K	ACH-000416	Lung Cancer	CCLE	VRAPLSTLN	DEG_APCC_DBOX_1	0.2778
p.E135K	NCI-H838	lung	COSMIC	VRAPLSTLN	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P41134	DNA-binding protein inhibitor ID-1	DEG_APCC_DBOX_1	125:133	VRAPLSTLN	APC,CDC20,FZR1	0.9919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons