DegronMD - P41221(WNT5A)

GO - Biological processes (BP): activation of GTPase activity [GO:0090630]; activation of protein kinase B activity [GO:0032148]; anterior/posterior axis specification, embryo [GO:0008595]; atrial septum development [GO:0003283]; axon guidance [GO:0007411]; canonical Wnt signaling pathway [GO:0060070]; cartilage development [GO:0051216]; cell fate commitment [GO:0045165]; cellular protein localization [GO:0034613]; cellular response to calcium ion [GO:0071277]; cellular response to interferon-gamma [GO:0071346]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cervix development [GO:0060067]; chemoattraction of serotonergic neuron axon [GO:0036517]; chemorepulsion of dopaminergic neuron axon [GO:0036518]; cochlea morphogenesis [GO:0090103]; convergent extension involved in axis elongation [GO:0060028]; convergent extension involved in organogenesis [GO:0060029]; embryonic digit morphogenesis [GO:0042733]; embryonic skeletal system development [GO:0048706]; epithelial cell proliferation involved in mammary gland duct elongation [GO:0060750]; epithelial to mesenchymal transition [GO:0001837]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of planar polarity [GO:0001736]; excitatory synapse assembly [GO:1904861]; face development [GO:0060324]; genitalia development [GO:0048806]; heart looping [GO:0001947]; hematopoietic stem cell proliferation [GO:0071425]; hindgut morphogenesis [GO:0007442]; hypophysis morphogenesis [GO:0048850]; inhibitory synapse assembly [GO:1904862]; JNK cascade [GO:0007254]; keratinocyte differentiation [GO:0030216]; kidney development [GO:0001822]; lateral sprouting involved in mammary gland duct morphogenesis [GO:0060599]; lens development in camera-type eye [GO:0002088]; lung development [GO:0030324]; male gonad development [GO:0008584]; mammary gland branching involved in thelarche [GO:0060744]; melanocyte proliferation [GO:0097325]; mesenchymal-epithelial cell signaling [GO:0060638]; mesodermal to mesenchymal transition involved in gastrulation [GO:0060809]; midgut development [GO:0007494]; negative regulation of apoptotic process [GO:0043066]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell proliferation in midbrain [GO:1904934]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of melanin biosynthetic process [GO:0048022]; negative regulation of mesenchymal cell proliferation [GO:0072201]; negative regulation of prostatic bud formation [GO:0060686]; negative regulation of synapse assembly [GO:0051964]; negative regulation of transcription, DNA-templated [GO:0045892]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; non-canonical Wnt signaling pathway via JNK cascade [GO:0038031]; notochord morphogenesis [GO:0048570]; olfactory bulb interneuron development [GO:0021891]; optic cup formation involved in camera-type eye development [GO:0003408]; paraxial mesoderm formation [GO:0048341]; planar cell polarity pathway involved in axis elongation [GO:0003402]; planar cell polarity pathway involved in axon guidance [GO:1904938]; planar cell polarity pathway involved in cardiac muscle tissue morphogenesis [GO:0061350]; planar cell polarity pathway involved in cardiac right atrium morphogenesis [GO:0061349]; planar cell polarity pathway involved in gastrula mediolateral intercalation [GO:0060775]; planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation [GO:1904955]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; planar cell polarity pathway involved in outflow tract morphogenesis [GO:0061347]; planar cell polarity pathway involved in pericardium morphogenesis [GO:0061354]; planar cell polarity pathway involved in ventricular septum morphogenesis [GO:0061348]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of endocytosis [GO:0045807]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway [GO:0090082]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of macrophage activation [GO:0043032]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of meiotic nuclear division [GO:0045836]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of neuron death [GO:1901216]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]; positive regulation of ossification [GO:0045778]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein binding [GO:0032092]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein kinase C activity [GO:1900020]; positive regulation of protein kinase C signaling [GO:0090037]; positive regulation of protein localization to synapse [GO:1902474]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of thymocyte apoptotic process [GO:0070245]; positive regulation of timing of anagen [GO:0051885]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; post-anal tail morphogenesis [GO:0036342]; postsynapse assembly [GO:0099068]; presynapse assembly [GO:0099054]; primary heart field specification [GO:0003138]; primitive streak formation [GO:0090009]; protein phosphorylation [GO:0006468]; regulation of branching involved in mammary gland duct morphogenesis [GO:0060762]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of inflammatory response [GO:0050727]; regulation of postsynapse organization [GO:0099175]; regulation of postsynaptic cytosolic calcium ion concentration [GO:0099566]; regulation of synapse organization [GO:0050807]; response to organic substance [GO:0010033]; secondary heart field specification [GO:0003139]; secondary palate development [GO:0062009]; somitogenesis [GO:0001756]; type B pancreatic cell development [GO:0003323]; urinary bladder development [GO:0060157]; uterus development [GO:0060065]; vagina development [GO:0060068]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, calcium modulating pathway [GO:0007223]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953]; wound healing [GO:0042060] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R277Q	TCGA-2W-A8YY	CESC	TCGA	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.25
p.R277Q	DO223732	CESC	ICGC	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.25
p.R277Q	DO227564	PACA	ICGC	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.25
p.R277L	TCGA-44-6774	LUAD	TCGA	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.25
p.R277L	DO25000	LUAD	ICGC	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.25
p.Q286H	TCGA-69-7979	LUAD	TCGA	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation altering degron motif	0.647
p.Q286H	DO23874	LUAD	ICGC	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation altering degron motif	0.647
p.A273T	TCGA-AX-A1C5	UCEC	TCGA	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.1389
p.A273T	DO41422	UCEC	ICGC	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.1389
p.K283R	TCGA-BR-6458	STAD	TCGA	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation altering degron motif	0.6126
p.K283R	DO38296	STAD	ICGC	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation altering degron motif	0.6126
p.G282C	TCGA-D3-A2JN	SKCM	TCGA	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation altering degron motif	0.6489
p.G282C	DO47590	SKCM	ICGC	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation altering degron motif	0.6489
p.A274V	TCGA-D7-A6EY	STAD	TCGA	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.1667
p.A274V	DO50118	STAD	ICGC	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.1667
p.R281W	TCGA-G4-6295	COAD	TCGA	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation altering degron motif	0.8634
p.R281W	DO9362	COAD	ICGC	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation altering degron motif	0.8634
p.R281W	DO233779	GACA	ICGC	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation altering degron motif	0.8634
p.R281Q	TCGA-YD-A9TA	SKCM	TCGA	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation altering degron motif	0.7329
p.R281Q	DO219503	SKCM	ICGC	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation altering degron motif	0.7329
p.D298Y	DO222884	COCA	ICGC	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.0556
p.D271N	DO234426	ESAD	ICGC	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.0833
p.R290S	SIDM00438	B-Lymphoblastic Leukemia	GDSC	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.2778
p.R290S	ACH-002275	Leukemia	CCLE	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.2778
p.R290S	MN-60	haematopoietic and lymphoid tissue	COSMIC	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.2778
p.R277W	ACH-001719	Ovarian Cancer	CCLE	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.25
p.R281P	ACH-002309	Sarcoma	CCLE	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation altering degron motif	0.7512
p.R281P	SW684	soft tissue	COSMIC	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation altering degron motif	0.7512
p.S293L	ACH-002357	Non-Cancerous	CCLE	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.1944
p.R275S	MN-60	haematopoietic and lymphoid tissue	COSMIC	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.1944
p.E298Q	NCI-H187	lung	COSMIC	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.0556
p.R296H	DG-75	haematopoietic and lymphoid tissue	COSMIC	SRGKLVQVN	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WNT5A

UniProt ID: P41221

Entrez ID: 7474

Protein name: Protein Wnt-5a

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WNT5A in