DegronMD

Uniprot ID: P41221

Source protein: Protein Wnt-5a

Source gene: WNT5A

Class: DEG_APCC_DBOX_1

Location: 280:288

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9802

ASA_SCORE: 94.0111

COIL: 0.8081

CONS_SCORE: 0.3555

DSS_SCORE: 0.3522

HELIX: 0.0266

FCONS_SCORE: 0.7751

RIG_SCORE: 0.7583

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R277Q	TCGA-2W-A8YY	CESC	TCGA	SRGKLVQVN	DEG_APCC_DBOX_1	0.25
p.R277Q	DO223732	CESC	ICGC	SRGKLVQVN	DEG_APCC_DBOX_1	0.25
p.R277Q	DO227564	PACA	ICGC	SRGKLVQVN	DEG_APCC_DBOX_1	0.25
p.R277L	TCGA-44-6774	LUAD	TCGA	SRGKLVQVN	DEG_APCC_DBOX_1	0.25
p.R277L	DO25000	LUAD	ICGC	SRGKLVQVN	DEG_APCC_DBOX_1	0.25
p.Q286H	TCGA-69-7979	LUAD	TCGA	SRGKLVQVN	DEG_APCC_DBOX_1	0.647
p.Q286H	DO23874	LUAD	ICGC	SRGKLVQVN	DEG_APCC_DBOX_1	0.647
p.A273T	TCGA-AX-A1C5	UCEC	TCGA	SRGKLVQVN	DEG_APCC_DBOX_1	0.1389
p.A273T	DO41422	UCEC	ICGC	SRGKLVQVN	DEG_APCC_DBOX_1	0.1389
p.K283R	TCGA-BR-6458	STAD	TCGA	SRGKLVQVN	DEG_APCC_DBOX_1	0.6126
p.K283R	DO38296	STAD	ICGC	SRGKLVQVN	DEG_APCC_DBOX_1	0.6126
p.G282C	TCGA-D3-A2JN	SKCM	TCGA	SRGKLVQVN	DEG_APCC_DBOX_1	0.6489
p.G282C	DO47590	SKCM	ICGC	SRGKLVQVN	DEG_APCC_DBOX_1	0.6489
p.A274V	TCGA-D7-A6EY	STAD	TCGA	SRGKLVQVN	DEG_APCC_DBOX_1	0.1667
p.A274V	DO50118	STAD	ICGC	SRGKLVQVN	DEG_APCC_DBOX_1	0.1667
p.R281W	TCGA-G4-6295	COAD	TCGA	SRGKLVQVN	DEG_APCC_DBOX_1	0.8634
p.R281W	DO9362	COAD	ICGC	SRGKLVQVN	DEG_APCC_DBOX_1	0.8634
p.R281W	DO233779	GACA	ICGC	SRGKLVQVN	DEG_APCC_DBOX_1	0.8634
p.R281Q	TCGA-YD-A9TA	SKCM	TCGA	SRGKLVQVN	DEG_APCC_DBOX_1	0.7329
p.R281Q	DO219503	SKCM	ICGC	SRGKLVQVN	DEG_APCC_DBOX_1	0.7329
p.D298Y	DO222884	COCA	ICGC	SRGKLVQVN	DEG_APCC_DBOX_1	0.0556
p.D271N	DO234426	ESAD	ICGC	SRGKLVQVN	DEG_APCC_DBOX_1	0.0833
p.R290S	SIDM00438	B-Lymphoblastic Leukemia	GDSC	SRGKLVQVN	DEG_APCC_DBOX_1	0.2778
p.R290S	ACH-002275	Leukemia	CCLE	SRGKLVQVN	DEG_APCC_DBOX_1	0.2778
p.R290S	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	SRGKLVQVN	DEG_APCC_DBOX_1	0.2778
p.R277W	ACH-001719	Ovarian Cancer	CCLE	SRGKLVQVN	DEG_APCC_DBOX_1	0.25
p.R281P	ACH-002309	Sarcoma	CCLE	SRGKLVQVN	DEG_APCC_DBOX_1	0.7512
p.R281P	SW684	soft_tissue	COSMIC	SRGKLVQVN	DEG_APCC_DBOX_1	0.7512
p.S293L	ACH-002357	Non-Cancerous	CCLE	SRGKLVQVN	DEG_APCC_DBOX_1	0.1944
p.R275S	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	SRGKLVQVN	DEG_APCC_DBOX_1	0.1944
p.E298Q	NCI-H187	lung	COSMIC	SRGKLVQVN	DEG_APCC_DBOX_1	0.0556
p.R296H	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	SRGKLVQVN	DEG_APCC_DBOX_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRGKLVQVN

Degron related mutations and impact score

Drug responses associated with WNT5A mutations

All proteins holding degron of SRGKLVQVN

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P41221	Protein Wnt-5a	DEG_APCC_DBOX_1	280:288	SRGKLVQVN	APC,CDC20,FZR1	0.9802	More...