DegronMD - P41225(SOX3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R391H	TCGA-HU-A4GT	STAD	TCGA	QRACLGDLR	DEG_APCC_DBOX_1	390:398	Mutation altering degron motif	0.8244
p.R391H	DO48020	STAD	ICGC	QRACLGDLR	DEG_APCC_DBOX_1	390:398	Mutation altering degron motif	0.8244
p.A392V	DO233114	GACA	ICGC	QRACLGDLR	DEG_APCC_DBOX_1	390:398	Mutation altering degron motif	0.5825
p.S380L	SIDM02016	Colorectal Carcinoma	GDSC	QRACLGDLR	DEG_APCC_DBOX_1	390:398	Mutation blocking phosphorylation signal	0.5
p.A392T	SIDM00282	Colorectal Carcinoma	GDSC	QRACLGDLR	DEG_APCC_DBOX_1	390:398	Mutation altering degron motif	0.6028
p.A392T	ACH-000998	Colon/Colorectal Cancer	CCLE	QRACLGDLR	DEG_APCC_DBOX_1	390:398	Mutation altering degron motif	0.6028
p.L394F	SIDM00397	Acute Myeloid Leukemia	GDSC	QRACLGDLR	DEG_APCC_DBOX_1	390:398	Mutation altering degron motif	0.6981
p.L394F	ACH-000195	Leukemia	CCLE	QRACLGDLR	DEG_APCC_DBOX_1	390:398	Mutation altering degron motif	0.6981
p.A386T	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	QRACLGDLR	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.2222
p.A386T	ACH-001638	Lymphoma	CCLE	QRACLGDLR	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.2222
p.D399E	ACH-000945	Lung Cancer	CCLE	QRACLGDLR	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.3056
p.R398H	ACH-000995	Leukemia	CCLE	QRACLGDLR	DEG_APCC_DBOX_1	390:398	Mutation altering degron motif	0.7133
p.M400T	ACH-001737	Leukemia	CCLE	QRACLGDLR	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons