DegronMD

Uniprot ID: P41225

Source protein: Transcription factor SOX-3

Source gene: SOX3

Class: DEG_APCC_DBOX_1

Location: 390:398

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9782

ASA_SCORE: 82.3222

COIL: 0.6597

CONS_SCORE: 0.4667

DSS_SCORE: 0.4322

HELIX: 0.3143

FCONS_SCORE: 0.9981

RIG_SCORE: 0.7518

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R391H	TCGA-HU-A4GT	STAD	TCGA	QRACLGDLR	DEG_APCC_DBOX_1	0.8244
p.R391H	DO48020	STAD	ICGC	QRACLGDLR	DEG_APCC_DBOX_1	0.8244
p.A392V	DO233114	GACA	ICGC	QRACLGDLR	DEG_APCC_DBOX_1	0.5825
p.S380L	SIDM02016	Colorectal Carcinoma	GDSC	QRACLGDLR	DEG_APCC_DBOX_1	0.5
p.A392T	SIDM00282	Colorectal Carcinoma	GDSC	QRACLGDLR	DEG_APCC_DBOX_1	0.6028
p.A392T	ACH-000998	Colon/Colorectal Cancer	CCLE	QRACLGDLR	DEG_APCC_DBOX_1	0.6028
p.L394F	SIDM00397	Acute Myeloid Leukemia	GDSC	QRACLGDLR	DEG_APCC_DBOX_1	0.6981
p.L394F	ACH-000195	Leukemia	CCLE	QRACLGDLR	DEG_APCC_DBOX_1	0.6981
p.A386T	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	QRACLGDLR	DEG_APCC_DBOX_1	0.2222
p.A386T	ACH-001638	Lymphoma	CCLE	QRACLGDLR	DEG_APCC_DBOX_1	0.2222
p.D399E	ACH-000945	Lung Cancer	CCLE	QRACLGDLR	DEG_APCC_DBOX_1	0.3056
p.R398H	ACH-000995	Leukemia	CCLE	QRACLGDLR	DEG_APCC_DBOX_1	0.7133
p.M400T	ACH-001737	Leukemia	CCLE	QRACLGDLR	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P41225	Transcription factor SOX-3	DEG_APCC_DBOX_1	390:398	QRACLGDLR	APC,CDC20,FZR1	0.9782	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons