DegronMD - P41235(HNF4A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E444K	TCGA-55-8621	LUAD	TCGA	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation rewiring degron network	0.1111
p.P430S	TCGA-AA-3693	COAD	TCGA	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation altering degron motif	0.6752
p.G439C	TCGA-AG-A02N	READ	TCGA	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation rewiring degron network	0.25
p.P433S	TCGA-DA-A1IC	SKCM	TCGA	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation altering degron motif	0.6752
p.P437S	TCGA-EB-A3Y7	SKCM	TCGA	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation rewiring degron network	0.3056
p.G442E	TCGA-EE-A29C	SKCM	TCGA	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation rewiring degron network	0.1667
p.G425R	TCGA-EE-A29D	SKCM	TCGA	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation rewiring degron network	0.1944
p.R422Q	TCGA-EE-A3J5	SKCM	TCGA	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation rewiring degron network	0.1111
p.T432I	TCGA-FR-A3YO	SKCM	TCGA	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation altering degron motif	0.8189
p.S443Y	TCGA-NJ-A4YQ	LUAD	TCGA	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation blocking phosphorylation signal	0.5833
p.V435I	DO219107	GBM	ICGC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation altering degron motif	0.7076
p.S421Y	DO218944	LUAD	ICGC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation rewiring degron network	0.0833
p.E434K	DO25406	LUAD	ICGC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation altering degron motif	0.7022
p.A430D	DO230998	LUSC	ICGC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation altering degron motif	0.7793
p.A430D	DO224576	LUSC	ICGC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation altering degron motif	0.7793
p.L438V	DO231010	LUSC	ICGC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation rewiring degron network	0.2778
p.A430V	DO220877	MELA	ICGC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation altering degron motif	0.6936
p.G432E	DO222727	MELA	ICGC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation altering degron motif	0.7199
p.G432E	DO38028	SKCM	ICGC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation altering degron motif	0.7199
p.P420R	DO228147	PBCA	ICGC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation rewiring degron network	0.0556
p.P427S	DO37499	SKCM	ICGC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation rewiring degron network	0.25
p.P423S	DO37430	SKCM	ICGC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation rewiring degron network	0.1389
p.V431I	DO38567	STAD	ICGC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation altering degron motif	0.7076
p.T445A	DO41871	UCEC	ICGC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation rewiring degron network	0.0833
p.G440S	SIDM01624	Bladder Carcinoma	GDSC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation rewiring degron network	0.2222
p.G440S	SIDM01529	Bladder Carcinoma	GDSC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation rewiring degron network	0.2222
p.G440S	ACH-000011	Bladder Cancer	CCLE	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation rewiring degron network	0.2222
p.G440S	ACH-000026	Bladder Cancer	CCLE	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation rewiring degron network	0.2222
p.T437I	MCC26	skin	COSMIC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation rewiring degron network	0.3056
p.E440K	SW684	soft tissue	COSMIC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation rewiring degron network	0.2222
p.T444I	MCC26	skin	COSMIC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation rewiring degron network	0.1111
p.I441T	SNU-175	large intestine	COSMIC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation blocking phosphorylation signal	0.6389
p.G429E	SK-MEL-28	skin	COSMIC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation blocking phosphorylation signal	0.75
p.G426R	SK-MEL-28	skin	COSMIC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation rewiring degron network	0.2222
p.P434L	TOV-21G	ovary	COSMIC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation altering degron motif	0.7582
p.I438T	SNU-175	large intestine	COSMIC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation rewiring degron network	0.2778
p.G441E	SK-MEL-28	skin	COSMIC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation blocking phosphorylation signal	0.6389
p.G429R	SK-MEL-28	skin	COSMIC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation blocking phosphorylation signal	0.75
p.I431T	SNU-175	large intestine	COSMIC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation altering degron motif	0.7078
p.P441L	TOV-21G	ovary	COSMIC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation blocking phosphorylation signal	0.6389
p.I442T	C-33-A	cervix	COSMIC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation rewiring degron network	0.1667
p.G441R	SK-MEL-28	skin	COSMIC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation blocking phosphorylation signal	0.6389
p.P444L	TOV-21G	ovary	COSMIC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation rewiring degron network	0.1111
p.G426E	SK-MEL-28	skin	COSMIC	PETPQPS	DEG_SCF_FBW7_1	430:436	Mutation rewiring degron network	0.2222

Kaplan plot for HNF4A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HNF4A

UniProt ID: P41235

Entrez ID: 3172

Protein name: Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HNF4A in