DegronMD

Uniprot ID: P41235

Source protein: Hepatocyte nuclear factor 4-alpha

Source gene: HNF4A

Class: DEG_SCF_FBW7_1

Location: 430:436

E3 ligase: FBXW7

DEGRON score: 0.8099

ASA_SCORE: 95.7143

COIL: 0.9496

CONS_SCORE: 0.4523

DSS_SCORE: 0.8486

HELIX: 0.0083

FCONS_SCORE: 1.1974

RIG_SCORE: 0.5467

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E444K	TCGA-55-8621	LUAD	TCGA	PETPQPS	DEG_SCF_FBW7_1	0.1111
p.P430S	TCGA-AA-3693	COAD	TCGA	PETPQPS	DEG_SCF_FBW7_1	0.6752
p.G439C	TCGA-AG-A02N	READ	TCGA	PETPQPS	DEG_SCF_FBW7_1	0.25
p.P433S	TCGA-DA-A1IC	SKCM	TCGA	PETPQPS	DEG_SCF_FBW7_1	0.6752
p.P437S	TCGA-EB-A3Y7	SKCM	TCGA	PETPQPS	DEG_SCF_FBW7_1	0.3056
p.G442E	TCGA-EE-A29C	SKCM	TCGA	PETPQPS	DEG_SCF_FBW7_1	0.1667
p.G425R	TCGA-EE-A29D	SKCM	TCGA	PETPQPS	DEG_SCF_FBW7_1	0.1944
p.R422Q	TCGA-EE-A3J5	SKCM	TCGA	PETPQPS	DEG_SCF_FBW7_1	0.1111
p.T432I	TCGA-FR-A3YO	SKCM	TCGA	PETPQPS	DEG_SCF_FBW7_1	0.8189
p.S443Y	TCGA-NJ-A4YQ	LUAD	TCGA	PETPQPS	DEG_SCF_FBW7_1	0.5833
p.V435I	DO219107	GBM	ICGC	PETPQPS	DEG_SCF_FBW7_1	0.7076
p.S421Y	DO218944	LUAD	ICGC	PETPQPS	DEG_SCF_FBW7_1	0.0833
p.E434K	DO25406	LUAD	ICGC	PETPQPS	DEG_SCF_FBW7_1	0.7022
p.A430D	DO230998	LUSC	ICGC	PETPQPS	DEG_SCF_FBW7_1	0.7793
p.A430D	DO224576	LUSC	ICGC	PETPQPS	DEG_SCF_FBW7_1	0.7793
p.L438V	DO231010	LUSC	ICGC	PETPQPS	DEG_SCF_FBW7_1	0.2778
p.A430V	DO220877	MELA	ICGC	PETPQPS	DEG_SCF_FBW7_1	0.6936
p.G432E	DO222727	MELA	ICGC	PETPQPS	DEG_SCF_FBW7_1	0.7199
p.G432E	DO38028	SKCM	ICGC	PETPQPS	DEG_SCF_FBW7_1	0.7199
p.P420R	DO228147	PBCA	ICGC	PETPQPS	DEG_SCF_FBW7_1	0.0556
p.P427S	DO37499	SKCM	ICGC	PETPQPS	DEG_SCF_FBW7_1	0.25
p.P423S	DO37430	SKCM	ICGC	PETPQPS	DEG_SCF_FBW7_1	0.1389
p.V431I	DO38567	STAD	ICGC	PETPQPS	DEG_SCF_FBW7_1	0.7076
p.T445A	DO41871	UCEC	ICGC	PETPQPS	DEG_SCF_FBW7_1	0.0833
p.G440S	SIDM01624	Bladder Carcinoma	GDSC	PETPQPS	DEG_SCF_FBW7_1	0.2222
p.G440S	SIDM01529	Bladder Carcinoma	GDSC	PETPQPS	DEG_SCF_FBW7_1	0.2222
p.G440S	ACH-000011	Bladder Cancer	CCLE	PETPQPS	DEG_SCF_FBW7_1	0.2222
p.G440S	ACH-000026	Bladder Cancer	CCLE	PETPQPS	DEG_SCF_FBW7_1	0.2222
p.T437I	MCC26	skin	COSMIC	PETPQPS	DEG_SCF_FBW7_1	0.3056
p.E440K	SW684	soft_tissue	COSMIC	PETPQPS	DEG_SCF_FBW7_1	0.2222
p.T444I	MCC26	skin	COSMIC	PETPQPS	DEG_SCF_FBW7_1	0.1111
p.I441T	SNU-175	large_intestine	COSMIC	PETPQPS	DEG_SCF_FBW7_1	0.6389
p.G429E	SK-MEL-28	skin	COSMIC	PETPQPS	DEG_SCF_FBW7_1	0.75
p.G426R	SK-MEL-28	skin	COSMIC	PETPQPS	DEG_SCF_FBW7_1	0.2222
p.P434L	TOV-21G	ovary	COSMIC	PETPQPS	DEG_SCF_FBW7_1	0.7582
p.I438T	SNU-175	large_intestine	COSMIC	PETPQPS	DEG_SCF_FBW7_1	0.2778
p.G441E	SK-MEL-28	skin	COSMIC	PETPQPS	DEG_SCF_FBW7_1	0.6389
p.G429R	SK-MEL-28	skin	COSMIC	PETPQPS	DEG_SCF_FBW7_1	0.75
p.I431T	SNU-175	large_intestine	COSMIC	PETPQPS	DEG_SCF_FBW7_1	0.7078
p.P441L	TOV-21G	ovary	COSMIC	PETPQPS	DEG_SCF_FBW7_1	0.6389
p.I442T	C-33-A	cervix	COSMIC	PETPQPS	DEG_SCF_FBW7_1	0.1667
p.G441R	SK-MEL-28	skin	COSMIC	PETPQPS	DEG_SCF_FBW7_1	0.6389
p.P444L	TOV-21G	ovary	COSMIC	PETPQPS	DEG_SCF_FBW7_1	0.1111
p.G426E	SK-MEL-28	skin	COSMIC	PETPQPS	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PETPQPS

Degron related mutations and impact score

Drug responses associated with HNF4A mutations

All proteins holding degron of PETPQPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P41235	Hepatocyte nuclear factor 4-alpha	DEG_SCF_FBW7_1	430:436	PETPQPS	FBXW7	0.8099	More...