DegronMD

Uniprot ID: P41235

Source protein: Hepatocyte nuclear factor 4-alpha

Source gene: HNF4A

Class: DEG_SCF_FBW7_1

Location: 430:436

E3 ligase: FBXW7

DEGRON score: 0.8099

ASA_SCORE: 95.7143

COIL: 0.9496

CONS_SCORE: 0.4523

DSS_SCORE: 0.8486

HELIX: 0.0083

FCONS_SCORE: 1.1974

RIG_SCORE: 0.5467

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T432I	TCGA-FR-A3YO	SKCM	TCGA	PETPQPS	DEG_SCF_FBW7_1	0.8189
p.A430D	DO230998	LUSC	ICGC	PETPQPS	DEG_SCF_FBW7_1	0.7793
p.A430D	DO224576	LUSC	ICGC	PETPQPS	DEG_SCF_FBW7_1	0.7793
p.P434L	TOV-21G	ovary	COSMIC	PETPQPS	DEG_SCF_FBW7_1	0.7582
p.G429E	SK-MEL-28	skin	COSMIC	PETPQPS	DEG_SCF_FBW7_1	0.75
p.G429R	SK-MEL-28	skin	COSMIC	PETPQPS	DEG_SCF_FBW7_1	0.75
p.G432E	DO222727	MELA	ICGC	PETPQPS	DEG_SCF_FBW7_1	0.7199
p.G432E	DO38028	SKCM	ICGC	PETPQPS	DEG_SCF_FBW7_1	0.7199
p.I431T	SNU-175	large_intestine	COSMIC	PETPQPS	DEG_SCF_FBW7_1	0.7078
p.V435I	DO219107	GBM	ICGC	PETPQPS	DEG_SCF_FBW7_1	0.7076
p.V431I	DO38567	STAD	ICGC	PETPQPS	DEG_SCF_FBW7_1	0.7076
p.E434K	DO25406	LUAD	ICGC	PETPQPS	DEG_SCF_FBW7_1	0.7022
p.A430V	DO220877	MELA	ICGC	PETPQPS	DEG_SCF_FBW7_1	0.6936
p.P430S	TCGA-AA-3693	COAD	TCGA	PETPQPS	DEG_SCF_FBW7_1	0.6752
p.P433S	TCGA-DA-A1IC	SKCM	TCGA	PETPQPS	DEG_SCF_FBW7_1	0.6752
p.I441T	SNU-175	large_intestine	COSMIC	PETPQPS	DEG_SCF_FBW7_1	0.6389
p.G441E	SK-MEL-28	skin	COSMIC	PETPQPS	DEG_SCF_FBW7_1	0.6389
p.P441L	TOV-21G	ovary	COSMIC	PETPQPS	DEG_SCF_FBW7_1	0.6389
p.G441R	SK-MEL-28	skin	COSMIC	PETPQPS	DEG_SCF_FBW7_1	0.6389
p.S443Y	TCGA-NJ-A4YQ	LUAD	TCGA	PETPQPS	DEG_SCF_FBW7_1	0.5833
p.P437S	TCGA-EB-A3Y7	SKCM	TCGA	PETPQPS	DEG_SCF_FBW7_1	0.3056
p.T437I	MCC26	skin	COSMIC	PETPQPS	DEG_SCF_FBW7_1	0.3056
p.L438V	DO231010	LUSC	ICGC	PETPQPS	DEG_SCF_FBW7_1	0.2778
p.I438T	SNU-175	large_intestine	COSMIC	PETPQPS	DEG_SCF_FBW7_1	0.2778
p.G439C	TCGA-AG-A02N	READ	TCGA	PETPQPS	DEG_SCF_FBW7_1	0.25

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P41235	Hepatocyte nuclear factor 4-alpha	DEG_SCF_FBW7_1	430:436	PETPQPS	FBXW7	0.8099	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons