TXK
UniProt ID: P42681
Entrez ID: 7294
Protein name: Tyrosine-protein kinase TXK (EC 2.7.10.2) (Protein-tyrosine kinase 4) (Resting lymphocyte kinase)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR)...
FUNCTION: Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with PARP1 and EEF1A1 (PubMed:11859127, PubMed:17177976). Within the complex, phosphorylates both PARP1 and EEF1A1 (PubMed:17177976). Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor. {ECO:0000269|PubMed:10523612, ECO:0000269|PubMed:11564877, ECO:0000269|PubMed:11859127, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:9813138}.
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GO - Biological processes (BP):
activation of phospholipase C activity [GO:0007202]; adaptive immune response [GO:0002250]; integrin-mediated signaling pathway [GO:0007229]; peptidyl-tyrosine autophosphorylation [GO:0038083]; positive regulation of cytokine production [GO:0001819]; positive regulation of interferon-gamma-mediated ...
activation of phospholipase C activity [GO:0007202]; adaptive immune response [GO:0002250]; integrin-mediated signaling pathway [GO:0007229]; peptidyl-tyrosine autophosphorylation [GO:0038083]; positive regulation of cytokine production [GO:0001819]; positive regulation of interferon-gamma-mediated signaling pathway [GO:0060335]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of gene expression [GO:0010468]; regulation of platelet activation [GO:0010543]; T cell receptor signaling pathway [GO:0050852]; tissue regeneration [GO:0042246]
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GO - Molecular function (MF):
ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]...
ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]...
cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]
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TXK
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*NOTE: the Kaplan plots were collected from OncoLnc