DegronMD

Uniprot ID: P42681

Source protein: Tyrosine-protein kinase TXK

Source gene: TXK

Class: DEG_APCC_DBOX_1

Location: 68:76

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.956

ASA_SCORE: 103.5889

COIL: 0.9596

CONS_SCORE: 0.5053

DSS_SCORE: 0.6876

HELIX: 0.0137

FCONS_SCORE: 1.3603

RIG_SCORE: 0.593

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R63H	TCGA-AA-3984	COAD	TCGA	KRKPLPPLP	DEG_APCC_DBOX_1	0.1944
p.R63H	TCGA-BG-A221	UCEC	TCGA	KRKPLPPLP	DEG_APCC_DBOX_1	0.1944
p.R63H	DO9002	COAD	ICGC	KRKPLPPLP	DEG_APCC_DBOX_1	0.1944
p.R63H	DO42384	UCEC	ICGC	KRKPLPPLP	DEG_APCC_DBOX_1	0.1944
p.R69Q	TCGA-AX-A05Z	UCEC	TCGA	KRKPLPPLP	DEG_APCC_DBOX_1	0.7329
p.R69Q	TCGA-CA-6718	COAD	TCGA	KRKPLPPLP	DEG_APCC_DBOX_1	0.7329
p.R69Q	DO7801	COAD	ICGC	KRKPLPPLP	DEG_APCC_DBOX_1	0.7329
p.R69Q	DO40884	UCEC	ICGC	KRKPLPPLP	DEG_APCC_DBOX_1	0.7329
p.T61M	TCGA-QQ-A8VF	SARC	TCGA	KRKPLPPLP	DEG_APCC_DBOX_1	0.1389
p.T61M	DO220258	SARC	ICGC	KRKPLPPLP	DEG_APCC_DBOX_1	0.1389
p.I85F	TCGA-ZC-AAA7	THYM	TCGA	KRKPLPPLP	DEG_APCC_DBOX_1	0.0833
p.L72M	DO229045	LICA	ICGC	KRKPLPPLP	DEG_APCC_DBOX_1	0.711
p.P66L	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	KRKPLPPLP	DEG_APCC_DBOX_1	0.2778
p.P66L	ACH-001233	Lung Cancer	CCLE	KRKPLPPLP	DEG_APCC_DBOX_1	0.2778
p.P66L	VMRC-LCD	lung	COSMIC	KRKPLPPLP	DEG_APCC_DBOX_1	0.2778
p.F83Y	RL95-2	endometrium	COSMIC	KRKPLPPLP	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42681	Tyrosine-protein kinase TXK	DEG_APCC_DBOX_1	68:76	KRKPLPPLP	APC,CDC20,FZR1	0.956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons