DegronMD - P43155(CRAT)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R369W	TCGA-AD-6965	COAD	TCGA	VRSPLVPLP	DEG_APCC_DBOX_1	368:376	Mutation altering degron motif	0.8634
p.R369W	DO228246	BRCA	ICGC	VRSPLVPLP	DEG_APCC_DBOX_1	368:376	Mutation altering degron motif	0.8634
p.R369W	DO9018	COAD	ICGC	VRSPLVPLP	DEG_APCC_DBOX_1	368:376	Mutation altering degron motif	0.8634
p.R369W	SIDM01090	Colorectal Carcinoma	GDSC	VRSPLVPLP	DEG_APCC_DBOX_1	368:376	Mutation altering degron motif	0.8634
p.R369W	ACH-000943	Colon/Colorectal Cancer	CCLE	VRSPLVPLP	DEG_APCC_DBOX_1	368:376	Mutation altering degron motif	0.8634
p.R369W	RKO	large intestine	COSMIC	VRSPLVPLP	DEG_APCC_DBOX_1	368:376	Mutation altering degron motif	0.8634
p.R382W	TCGA-AX-A1CE	UCEC	TCGA	VRSPLVPLP	DEG_APCC_DBOX_1	368:376	Mutation rewiring degron network	0.1667
p.R382W	DO42280	UCEC	ICGC	VRSPLVPLP	DEG_APCC_DBOX_1	368:376	Mutation rewiring degron network	0.1667
p.K380N	TCGA-CI-6621	READ	TCGA	VRSPLVPLP	DEG_APCC_DBOX_1	368:376	Mutation blocking ubiquitination signal	0.6667
p.K380N	DO36970	READ	ICGC	VRSPLVPLP	DEG_APCC_DBOX_1	368:376	Mutation blocking ubiquitination signal	0.6667
p.R369Q	TCGA-L5-A8NE	ESCA	TCGA	VRSPLVPLP	DEG_APCC_DBOX_1	368:376	Mutation altering degron motif	0.7329
p.L372M	DO229010	COCA	ICGC	VRSPLVPLP	DEG_APCC_DBOX_1	368:376	Mutation altering degron motif	0.711
p.L372M	DO229013	COCA	ICGC	VRSPLVPLP	DEG_APCC_DBOX_1	368:376	Mutation altering degron motif	0.711
p.L372M	DO229016	COCA	ICGC	VRSPLVPLP	DEG_APCC_DBOX_1	368:376	Mutation altering degron motif	0.711
p.L372M	DO229003	COCA	ICGC	VRSPLVPLP	DEG_APCC_DBOX_1	368:376	Mutation altering degron motif	0.711
p.L372M	DO229005	COCA	ICGC	VRSPLVPLP	DEG_APCC_DBOX_1	368:376	Mutation altering degron motif	0.711
p.E360G	DO229056	LICA	ICGC	VRSPLVPLP	DEG_APCC_DBOX_1	368:376	Mutation rewiring degron network	0.1111
p.P365S	DO50970	LICA	ICGC	VRSPLVPLP	DEG_APCC_DBOX_1	368:376	Mutation rewiring degron network	0.25
p.P376L	SIDM00683	Prostate Carcinoma	GDSC	VRSPLVPLP	DEG_APCC_DBOX_1	368:376	Mutation altering degron motif	0.6471
p.P376L	ACH-000977	lymph node	CCLE	VRSPLVPLP	DEG_APCC_DBOX_1	368:376	Mutation altering degron motif	0.6471
p.P376L	LNCaP-Clone-FGC	prostate	COSMIC	VRSPLVPLP	DEG_APCC_DBOX_1	368:376	Mutation altering degron motif	0.6471
p.T362S	SIDM00329	Hodgkin's Lymphoma	GDSC	VRSPLVPLP	DEG_APCC_DBOX_1	368:376	Mutation rewiring degron network	0.1667
p.T362S	L-540	haematopoietic and lymphoid tissue	COSMIC	VRSPLVPLP	DEG_APCC_DBOX_1	368:376	Mutation rewiring degron network	0.1667

Kaplan plot for CRAT in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CRAT

UniProt ID: P43155

Entrez ID: 1384

Protein name: Carnitine O-acetyltransferase (Carnitine acetylase) (EC 2.3.1.137) (EC 2.3.1.7) (Carnitine acetyltransferase) (CAT) (CrAT)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CRAT in