DegronMD

Uniprot ID: P43155

Source protein: Carnitine O-acetyltransferase

Source gene: CRAT

Class: DEG_APCC_DBOX_1

Location: 368:376

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.703

ASA_SCORE: 92.9111

COIL: 0.956

CONS_SCORE: 0.3823

DSS_SCORE: 0.2719

HELIX: 0.0204

FCONS_SCORE: 0.8404

RIG_SCORE: 0.7959

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R369W	TCGA-AD-6965	COAD	TCGA	VRSPLVPLP	DEG_APCC_DBOX_1	0.8634
p.R369W	DO228246	BRCA	ICGC	VRSPLVPLP	DEG_APCC_DBOX_1	0.8634
p.R369W	DO9018	COAD	ICGC	VRSPLVPLP	DEG_APCC_DBOX_1	0.8634
p.R369W	SIDM01090	Colorectal Carcinoma	GDSC	VRSPLVPLP	DEG_APCC_DBOX_1	0.8634
p.R369W	ACH-000943	Colon/Colorectal Cancer	CCLE	VRSPLVPLP	DEG_APCC_DBOX_1	0.8634
p.R369W	RKO	large_intestine	COSMIC	VRSPLVPLP	DEG_APCC_DBOX_1	0.8634
p.R369Q	TCGA-L5-A8NE	ESCA	TCGA	VRSPLVPLP	DEG_APCC_DBOX_1	0.7329
p.L372M	DO229010	COCA	ICGC	VRSPLVPLP	DEG_APCC_DBOX_1	0.711
p.L372M	DO229013	COCA	ICGC	VRSPLVPLP	DEG_APCC_DBOX_1	0.711
p.L372M	DO229016	COCA	ICGC	VRSPLVPLP	DEG_APCC_DBOX_1	0.711
p.L372M	DO229003	COCA	ICGC	VRSPLVPLP	DEG_APCC_DBOX_1	0.711
p.L372M	DO229005	COCA	ICGC	VRSPLVPLP	DEG_APCC_DBOX_1	0.711
p.K380N	TCGA-CI-6621	READ	TCGA	VRSPLVPLP	DEG_APCC_DBOX_1	0.6667
p.K380N	DO36970	READ	ICGC	VRSPLVPLP	DEG_APCC_DBOX_1	0.6667
p.P376L	SIDM00683	Prostate Carcinoma	GDSC	VRSPLVPLP	DEG_APCC_DBOX_1	0.6471
p.P376L	ACH-000977	lymph_node	CCLE	VRSPLVPLP	DEG_APCC_DBOX_1	0.6471
p.P376L	LNCaP-Clone-FGC	prostate	COSMIC	VRSPLVPLP	DEG_APCC_DBOX_1	0.6471
p.P365S	DO50970	LICA	ICGC	VRSPLVPLP	DEG_APCC_DBOX_1	0.25
p.R382W	TCGA-AX-A1CE	UCEC	TCGA	VRSPLVPLP	DEG_APCC_DBOX_1	0.1667
p.R382W	DO42280	UCEC	ICGC	VRSPLVPLP	DEG_APCC_DBOX_1	0.1667
p.T362S	SIDM00329	Hodgkin's Lymphoma	GDSC	VRSPLVPLP	DEG_APCC_DBOX_1	0.1667
p.T362S	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	VRSPLVPLP	DEG_APCC_DBOX_1	0.1667
p.E360G	DO229056	LICA	ICGC	VRSPLVPLP	DEG_APCC_DBOX_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P43155	Carnitine O-acetyltransferase	DEG_APCC_DBOX_1	368:376	VRSPLVPLP	APC,CDC20,FZR1	0.703	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons