DegronMD - P43351(RAD52)

FUNCTION: Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase. {ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:8702565}.

GO - Biological processes (BP): cellular response to DNA damage stimulus [GO:0006974]; cellular response to oxidative stress [GO:0034599]; DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; DNA recombinase assembly [GO:0000730]; DNA recombination [GO:0006310]; double-strand break repair... View more >>

GO - Molecular function (MF): DNA binding [GO:0003677]; identical protein binding [GO:0042802]; single-stranded DNA binding [GO:0003697]

GO - Cellular component (CC): nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
VSTPSAE	DEG_SCF_FBW7_2	FBXW7	DNA repair protein RAD52 homolog	279:285	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A282D	DO229028	LICA	ICGC	VSTPSAE	DEG_SCF_FBW7_2	279:285	Mutation altering degron motif	0.7793
p.S287G	TCGA-CG-5723	STAD	TCGA	VSTPSAE	DEG_SCF_FBW7_2	279:285	Mutation blocking phosphorylation signal	0.7222
p.N285K	DO229019	LICA	ICGC	VSTPSAE	DEG_SCF_FBW7_2	279:285	Mutation altering degron motif	0.6918
p.E285D	TCGA-EE-A2GI	SKCM	TCGA	VSTPSAE	DEG_SCF_FBW7_2	279:285	Mutation altering degron motif	0.6758
p.E285Q	TCGA-DK-A1AB	BLCA	TCGA	VSTPSAE	DEG_SCF_FBW7_2	279:285	Mutation altering degron motif	0.6744
p.Q286K	DO44832	LICA	ICGC	VSTPSAE	DEG_SCF_FBW7_2	279:285	Mutation rewiring degron network	0.3056
p.P286L	DO49762	PRAD	ICGC	VSTPSAE	DEG_SCF_FBW7_2	279:285	Mutation rewiring degron network	0.3056
p.A278T	DO43891	UCEC	ICGC	VSTPSAE	DEG_SCF_FBW7_2	279:285	Mutation rewiring degron network	0.3056
p.V277I	TCGA-B5-A11J	UCEC	TCGA	VSTPSAE	DEG_SCF_FBW7_2	279:285	Mutation rewiring degron network	0.2778
p.T277I	DO46591	OV	ICGC	VSTPSAE	DEG_SCF_FBW7_2	279:285	Mutation rewiring degron network	0.2778
p.T289I	DO233276	GACA	ICGC	VSTPSAE	DEG_SCF_FBW7_2	279:285	Mutation rewiring degron network	0.2222
p.Q290H	DO25613	LUAD	ICGC	VSTPSAE	DEG_SCF_FBW7_2	279:285	Mutation rewiring degron network	0.1944
p.N291K	DO229015	LICA	ICGC	VSTPSAE	DEG_SCF_FBW7_2	279:285	Mutation rewiring degron network	0.1667
p.P292R	TCGA-BA-A6DJ	HNSC	TCGA	VSTPSAE	DEG_SCF_FBW7_2	279:285	Mutation rewiring degron network	0.1389
p.A272T	DO51776	STAD	ICGC	VSTPSAE	DEG_SCF_FBW7_2	279:285	Mutation rewiring degron network	0.1389
p.A272T	DO38328	STAD	ICGC	VSTPSAE	DEG_SCF_FBW7_2	279:285	Mutation rewiring degron network	0.1389
p.R292M	DO41235	UCEC	ICGC	VSTPSAE	DEG_SCF_FBW7_2	279:285	Mutation rewiring degron network	0.1389
p.A293S	TCGA-FS-A1ZG	SKCM	TCGA	VSTPSAE	DEG_SCF_FBW7_2	279:285	Mutation rewiring degron network	0.1111
p.G294D	DO43698	UCEC	ICGC	VSTPSAE	DEG_SCF_FBW7_2	279:285	Mutation rewiring degron network	0.0833
p.P294S	DO41235	UCEC	ICGC	VSTPSAE	DEG_SCF_FBW7_2	279:285	Mutation rewiring degron network	0.0833

Showing 1 to 20 of 23 entries

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No resistance data available for this Degron.

Kaplan plot for RAD52 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAD52

UniProt ID: P43351

Entrez ID: 5893

Protein name: DNA repair protein RAD52 homolog

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for RAD52 in