DegronMD

Uniprot ID: P43351

Source protein: DNA repair protein RAD52 homolog

Source gene: RAD52

Class: DEG_SCF_FBW7_2

Location: 279:285

E3 ligase: FBXW7

DEGRON score: 0.9944

ASA_SCORE: 91.7857

COIL: 0.7743

CONS_SCORE: 0.3167

DSS_SCORE: 0.7109

HELIX: 0.2054

FCONS_SCORE: 1.1479

RIG_SCORE: 0.6079

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V277I	TCGA-B5-A11J	UCEC	TCGA	VSTPSAE	DEG_SCF_FBW7_2	0.2778
p.P292R	TCGA-BA-A6DJ	HNSC	TCGA	VSTPSAE	DEG_SCF_FBW7_2	0.1389
p.S287G	TCGA-CG-5723	STAD	TCGA	VSTPSAE	DEG_SCF_FBW7_2	0.7222
p.E285Q	TCGA-DK-A1AB	BLCA	TCGA	VSTPSAE	DEG_SCF_FBW7_2	0.6744
p.E285D	TCGA-EE-A2GI	SKCM	TCGA	VSTPSAE	DEG_SCF_FBW7_2	0.6758
p.R269W	TCGA-FC-A4JI	PRAD	TCGA	VSTPSAE	DEG_SCF_FBW7_2	0.0556
p.A293S	TCGA-FS-A1ZG	SKCM	TCGA	VSTPSAE	DEG_SCF_FBW7_2	0.1111
p.R269Q	DO474	BLCA	ICGC	VSTPSAE	DEG_SCF_FBW7_2	0.0556
p.T289I	DO233276	GACA	ICGC	VSTPSAE	DEG_SCF_FBW7_2	0.2222
p.H295N	DO229018	LICA	ICGC	VSTPSAE	DEG_SCF_FBW7_2	0.0556
p.N285K	DO229019	LICA	ICGC	VSTPSAE	DEG_SCF_FBW7_2	0.6918
p.N291K	DO229015	LICA	ICGC	VSTPSAE	DEG_SCF_FBW7_2	0.1667
p.A282D	DO229028	LICA	ICGC	VSTPSAE	DEG_SCF_FBW7_2	0.7793
p.Q286K	DO44832	LICA	ICGC	VSTPSAE	DEG_SCF_FBW7_2	0.3056
p.Q290H	DO25613	LUAD	ICGC	VSTPSAE	DEG_SCF_FBW7_2	0.1944
p.T277I	DO46591	OV	ICGC	VSTPSAE	DEG_SCF_FBW7_2	0.2778
p.P286L	DO49762	PRAD	ICGC	VSTPSAE	DEG_SCF_FBW7_2	0.3056
p.A272T	DO51776	STAD	ICGC	VSTPSAE	DEG_SCF_FBW7_2	0.1389
p.A272T	DO38328	STAD	ICGC	VSTPSAE	DEG_SCF_FBW7_2	0.1389
p.G294D	DO43698	UCEC	ICGC	VSTPSAE	DEG_SCF_FBW7_2	0.0833
p.P294S	DO41235	UCEC	ICGC	VSTPSAE	DEG_SCF_FBW7_2	0.0833
p.R292M	DO41235	UCEC	ICGC	VSTPSAE	DEG_SCF_FBW7_2	0.1389
p.A278T	DO43891	UCEC	ICGC	VSTPSAE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P43351	DNA repair protein RAD52 homolog	DEG_SCF_FBW7_2	279:285	VSTPSAE	FBXW7	0.9944	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons