DegronMD - P43354(NR4A2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R193H	TCGA-AP-A0LT	UCEC	TCGA	PPGTPVSS	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.2222
p.R193H	TCGA-HU-A4H3	STAD	TCGA	PPGTPVSS	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.2222
p.R193H	DO47903	STAD	ICGC	PPGTPVSS	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.2222
p.R193H	DO42681	UCEC	ICGC	PPGTPVSS	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.2222
p.D195N	TCGA-AP-A1DV	UCEC	TCGA	PPGTPVSS	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.1667
p.D195N	TCGA-BR-6801	STAD	TCGA	PPGTPVSS	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.1667
p.D195N	TCGA-EO-A3AY	UCEC	TCGA	PPGTPVSS	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.1667
p.D195N	DO38253	STAD	ICGC	PPGTPVSS	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.1667
p.D195N	DO43202	UCEC	ICGC	PPGTPVSS	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.1667
p.D195N	DO43186	UCEC	ICGC	PPGTPVSS	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.1667
p.G184V	TCGA-AX-A2HD	UCEC	TCGA	PPGTPVSS	DEG_SCF_FBW7_1	182:189	Mutation altering degron motif	0.6421
p.G184V	DO42608	UCEC	ICGC	PPGTPVSS	DEG_SCF_FBW7_1	182:189	Mutation altering degron motif	0.6421
p.R172H	TCGA-L5-A4OI	ESCA	TCGA	PPGTPVSS	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.0556
p.R172H	DO224950	BRCA	ICGC	PPGTPVSS	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.0556
p.R172C	DO233784	GACA	ICGC	PPGTPVSS	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.0556
p.R172C	DO229446	SKCA	ICGC	PPGTPVSS	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.0556
p.H199Q	DO228985	LICA	ICGC	PPGTPVSS	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.0556
p.D195E	DO229008	LICA	ICGC	PPGTPVSS	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.1667
p.S188F	SIDM00955	Melanoma	GDSC	PPGTPVSS	DEG_SCF_FBW7_1	182:189	Mutation altering degron motif	0.6871
p.S188F	ACH-000812	Skin Cancer	CCLE	PPGTPVSS	DEG_SCF_FBW7_1	182:189	Mutation altering degron motif	0.6871
p.S188F	COLO-783	skin	COSMIC	PPGTPVSS	DEG_SCF_FBW7_1	182:189	Mutation altering degron motif	0.6871
p.G184A	SIDM00007	Other Solid Cancers	GDSC	PPGTPVSS	DEG_SCF_FBW7_1	182:189	Mutation altering degron motif	0.6429
p.G184A	ACH-001550	Skin Cancer	CCLE	PPGTPVSS	DEG_SCF_FBW7_1	182:189	Mutation altering degron motif	0.6429
p.G184A	MCC13	skin	COSMIC	PPGTPVSS	DEG_SCF_FBW7_1	182:189	Mutation altering degron motif	0.6429
p.S190L	SNU-C5	large intestine	COSMIC	PPGTPVSS	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.3056

Kaplan plot for NR4A2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NR4A2

UniProt ID: P43354

Entrez ID: 4929

Protein name: Nuclear receptor subfamily 4 group A member 2 (Immediate-early response protein NOT) (Orphan nuclear receptor NURR1) (Transcriptionally-inducible nuclear receptor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NR4A2 in