DegronMD

Uniprot ID: P43354

Source protein: Nuclear receptor subfamily 4 group A member 2

Source gene: NR4A2

Class: DEG_SCF_FBW7_1

Location: 182:189

E3 ligase: FBXW7

DEGRON score: 0.998

ASA_SCORE: 59.475

COIL: 0.9291

CONS_SCORE: 0.4016

DSS_SCORE: 0.4969

HELIX: 0.0315

FCONS_SCORE: 1.0679

RIG_SCORE: 0.6145

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R193H	TCGA-AP-A0LT	UCEC	TCGA	PPGTPVSS	DEG_SCF_FBW7_1	0.2222
p.R193H	TCGA-HU-A4H3	STAD	TCGA	PPGTPVSS	DEG_SCF_FBW7_1	0.2222
p.R193H	DO47903	STAD	ICGC	PPGTPVSS	DEG_SCF_FBW7_1	0.2222
p.R193H	DO42681	UCEC	ICGC	PPGTPVSS	DEG_SCF_FBW7_1	0.2222
p.D195N	TCGA-AP-A1DV	UCEC	TCGA	PPGTPVSS	DEG_SCF_FBW7_1	0.1667
p.D195N	TCGA-BR-6801	STAD	TCGA	PPGTPVSS	DEG_SCF_FBW7_1	0.1667
p.D195N	TCGA-EO-A3AY	UCEC	TCGA	PPGTPVSS	DEG_SCF_FBW7_1	0.1667
p.D195N	DO38253	STAD	ICGC	PPGTPVSS	DEG_SCF_FBW7_1	0.1667
p.D195N	DO43202	UCEC	ICGC	PPGTPVSS	DEG_SCF_FBW7_1	0.1667
p.D195N	DO43186	UCEC	ICGC	PPGTPVSS	DEG_SCF_FBW7_1	0.1667
p.G184V	TCGA-AX-A2HD	UCEC	TCGA	PPGTPVSS	DEG_SCF_FBW7_1	0.6421
p.G184V	DO42608	UCEC	ICGC	PPGTPVSS	DEG_SCF_FBW7_1	0.6421
p.R172H	TCGA-L5-A4OI	ESCA	TCGA	PPGTPVSS	DEG_SCF_FBW7_1	0.0556
p.R172H	DO224950	BRCA	ICGC	PPGTPVSS	DEG_SCF_FBW7_1	0.0556
p.R172C	DO233784	GACA	ICGC	PPGTPVSS	DEG_SCF_FBW7_1	0.0556
p.R172C	DO229446	SKCA	ICGC	PPGTPVSS	DEG_SCF_FBW7_1	0.0556
p.H199Q	DO228985	LICA	ICGC	PPGTPVSS	DEG_SCF_FBW7_1	0.0556
p.D195E	DO229008	LICA	ICGC	PPGTPVSS	DEG_SCF_FBW7_1	0.1667
p.S188F	SIDM00955	Melanoma	GDSC	PPGTPVSS	DEG_SCF_FBW7_1	0.6871
p.S188F	ACH-000812	Skin Cancer	CCLE	PPGTPVSS	DEG_SCF_FBW7_1	0.6871
p.S188F	COLO-783	skin	COSMIC	PPGTPVSS	DEG_SCF_FBW7_1	0.6871
p.G184A	SIDM00007	Other Solid Cancers	GDSC	PPGTPVSS	DEG_SCF_FBW7_1	0.6429
p.G184A	ACH-001550	Skin Cancer	CCLE	PPGTPVSS	DEG_SCF_FBW7_1	0.6429
p.G184A	MCC13	skin	COSMIC	PPGTPVSS	DEG_SCF_FBW7_1	0.6429
p.S190L	SNU-C5	large_intestine	COSMIC	PPGTPVSS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P43354	Nuclear receptor subfamily 4 group A member 2	DEG_SCF_FBW7_1	182:189	PPGTPVSS	FBXW7	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons