DegronMD - P43626(KIR2DL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P318H	TCGA-A5-A0G2	UCEC	TCGA	DIIVYTELP	CBL_PTK	328:336	Mutation rewiring degron network	0.0556
p.P318H	DO41235	UCEC	ICGC	DIIVYTELP	CBL_PTK	328:336	Mutation rewiring degron network	0.0556
p.P322S	TCGA-BS-A0UV	UCEC	TCGA	DIIVYTELP	CBL_PTK	328:336	Mutation rewiring degron network	0.1667
p.P322S	DO42793	UCEC	ICGC	DIIVYTELP	CBL_PTK	328:336	Mutation rewiring degron network	0.1667
p.P326L	TCGA-T7-A92I	KIRC	TCGA	DIIVYTELP	CBL_PTK	328:336	Mutation rewiring degron network	0.2778
p.P326L	DO223834	KIRC	ICGC	DIIVYTELP	CBL_PTK	328:336	Mutation rewiring degron network	0.2778
p.S340F	SIDM01137	Pancreatic Carcinoma	GDSC	DIIVYTELP	CBL_PTK	328:336	Mutation rewiring degron network	0.2222
p.S340F	PANC-04-03	pancreas	COSMIC	DIIVYTELP	CBL_PTK	328:336	Mutation rewiring degron network	0.2222
p.S342Y	SIDM01136	Pancreatic Carcinoma	GDSC	DIIVYTELP	CBL_PTK	328:336	Mutation rewiring degron network	0.1667
p.S342Y	PANC-08-13	pancreas	COSMIC	DIIVYTELP	CBL_PTK	328:336	Mutation rewiring degron network	0.1667
p.K343N	SIDM00888	Other Solid Cancers	GDSC	DIIVYTELP	CBL_PTK	328:336	Mutation substituting flanking lysine	0.25
p.K343N	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	DIIVYTELP	CBL_PTK	328:336	Mutation substituting flanking lysine	0.25
p.K343N	SU-DHL-16	haematopoietic and lymphoid tissue	COSMIC	DIIVYTELP	CBL_PTK	328:336	Mutation substituting flanking lysine	0.25
p.K343N	D-283MED	central nervous system	COSMIC	DIIVYTELP	CBL_PTK	328:336	Mutation substituting flanking lysine	0.25
p.N337S	SIDM01147	Gastric Carcinoma	GDSC	DIIVYTELP	CBL_PTK	328:336	Mutation rewiring degron network	0.3056
p.N337S	SIDM00785	Acute Myeloid Leukemia	GDSC	DIIVYTELP	CBL_PTK	328:336	Mutation rewiring degron network	0.3056
p.N337S	SIDM01409	Bladder Carcinoma	GDSC	DIIVYTELP	CBL_PTK	328:336	Mutation rewiring degron network	0.3056
p.T333K	SIDM00986	Head and Neck Carcinoma	GDSC	DIIVYTELP	CBL_PTK	328:336	Mutation altering degron motif	0.7306
p.T333K	BHY	upper aerodigestive tract	COSMIC	DIIVYTELP	CBL_PTK	328:336	Mutation altering degron motif	0.7306
p.E334K	SIDM00225	Melanoma	GDSC	DIIVYTELP	CBL_PTK	328:336	Mutation altering degron motif	0.591
p.E334K	IST-MEL1	skin	COSMIC	DIIVYTELP	CBL_PTK	328:336	Mutation altering degron motif	0.591
p.V331L	SIDM00166	Other Solid Cancers	GDSC	DIIVYTELP	CBL_PTK	328:336	Mutation altering degron motif	0.5654
p.V331M	MDA-MB-468	breast	COSMIC	DIIVYTELP	CBL_PTK	328:336	Mutation altering degron motif	0.6097
p.V335I	MC-1010	haematopoietic and lymphoid tissue	COSMIC	DIIVYTELP	CBL_PTK	328:336	Mutation altering degron motif	0.7076
p.T342A	SNU-1040	large intestine	COSMIC	DIIVYTELP	CBL_PTK	328:336	Mutation rewiring degron network	0.1667

Kaplan plot for KIR2DL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIR2DL1

UniProt ID: P43626

Entrez ID: 3802

Protein name: Killer cell immunoglobulin-like receptor 2DL1 (CD158 antigen-like family member A) (Natural killer-associated transcript 1) (NKAT-1) (p58 natural killer cell receptor clones CL-42/47.11) (p58 NK receptor CL-42/47.11) (p58.1 MHC class-I-specific NK receptor) (CD antigen CD158a)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIR2DL1 in