DegronMD

Uniprot ID: P43626

Source protein: Killer cell immunoglobulin-like receptor 2DL1

Source gene: KIR2DL1

Class: CBL_PTK

Location: 328:336

E3 ligase: CBL

DEGRON score: 0.5501

ASA_SCORE: 46.8111

COIL: 0.4319

CONS_SCORE: 0.4081

DSS_SCORE: 0.5048

HELIX: 0.0086

FCONS_SCORE: 1.5444

RIG_SCORE: 0.8226

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T333K	SIDM00986	Head and Neck Carcinoma	GDSC	DIIVYTELP	CBL_PTK	0.7306
p.T333K	BHY	upper_aerodigestive_tract	COSMIC	DIIVYTELP	CBL_PTK	0.7306
p.V335I	MC-1010	haematopoietic_and_lymphoid_tissue	COSMIC	DIIVYTELP	CBL_PTK	0.7076
p.V331M	MDA-MB-468	breast	COSMIC	DIIVYTELP	CBL_PTK	0.6097
p.E334K	SIDM00225	Melanoma	GDSC	DIIVYTELP	CBL_PTK	0.591
p.E334K	IST-MEL1	skin	COSMIC	DIIVYTELP	CBL_PTK	0.591
p.V331L	SIDM00166	Other Solid Cancers	GDSC	DIIVYTELP	CBL_PTK	0.5654
p.N337S	SIDM01147	Gastric Carcinoma	GDSC	DIIVYTELP	CBL_PTK	0.3056
p.N337S	SIDM00785	Acute Myeloid Leukemia	GDSC	DIIVYTELP	CBL_PTK	0.3056
p.N337S	SIDM01409	Bladder Carcinoma	GDSC	DIIVYTELP	CBL_PTK	0.3056
p.P326L	TCGA-T7-A92I	KIRC	TCGA	DIIVYTELP	CBL_PTK	0.2778
p.P326L	DO223834	KIRC	ICGC	DIIVYTELP	CBL_PTK	0.2778
p.K343N	SIDM00888	Other Solid Cancers	GDSC	DIIVYTELP	CBL_PTK	0.25
p.K343N	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	DIIVYTELP	CBL_PTK	0.25
p.K343N	SU-DHL-16	haematopoietic_and_lymphoid_tissue	COSMIC	DIIVYTELP	CBL_PTK	0.25
p.K343N	D-283MED	central_nervous_system	COSMIC	DIIVYTELP	CBL_PTK	0.25
p.S340F	SIDM01137	Pancreatic Carcinoma	GDSC	DIIVYTELP	CBL_PTK	0.2222
p.S340F	PANC-04-03	pancreas	COSMIC	DIIVYTELP	CBL_PTK	0.2222
p.P322S	TCGA-BS-A0UV	UCEC	TCGA	DIIVYTELP	CBL_PTK	0.1667
p.P322S	DO42793	UCEC	ICGC	DIIVYTELP	CBL_PTK	0.1667
p.S342Y	SIDM01136	Pancreatic Carcinoma	GDSC	DIIVYTELP	CBL_PTK	0.1667
p.S342Y	PANC-08-13	pancreas	COSMIC	DIIVYTELP	CBL_PTK	0.1667
p.T342A	SNU-1040	large_intestine	COSMIC	DIIVYTELP	CBL_PTK	0.1667
p.P318H	TCGA-A5-A0G2	UCEC	TCGA	DIIVYTELP	CBL_PTK	0.0556
p.P318H	DO41235	UCEC	ICGC	DIIVYTELP	CBL_PTK	0.0556

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Drug responses associated with KIR2DL1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of DIIVYTELP

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P43626	Killer cell immunoglobulin-like receptor 2DL1	CBL_PTK	328:336	DIIVYTELP	CBL	0.5501	More...
P43628	Killer cell immunoglobulin-like receptor 2DL3	CBL_PTK	329:337	DIIVYTELP	CBL	0.9432	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DIIVYTELP

Degron related mutations and impact score

Drug responses associated with KIR2DL1 mutations

All proteins holding degron of DIIVYTELP