DegronMD - P43628(KIR2DL3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P323S	TCGA-24-1562	OV	TCGA	IIVYTE	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.1389
p.P323S	TCGA-24-1562	OV	TCGA	DIIVYTELP	CBL_PTK	329:337	Mutation rewiring degron network	0.1667
p.P323S	DO28412	OV	ICGC	IIVYTE	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.1389
p.P323S	DO28412	OV	ICGC	DIIVYTELP	CBL_PTK	329:337	Mutation rewiring degron network	0.1667
p.V332M	TCGA-2W-A8YY	CESC	TCGA	IIVYTE	LIG_APCC_ABBA_1	330:335	Mutation altering degron motif	0.6097
p.V332M	TCGA-2W-A8YY	CESC	TCGA	DIIVYTELP	CBL_PTK	329:337	Mutation altering degron motif	0.6097
p.V332M	DO223732	CESC	ICGC	IIVYTE	LIG_APCC_ABBA_1	330:335	Mutation altering degron motif	0.6097
p.V332M	DO223732	CESC	ICGC	DIIVYTELP	CBL_PTK	329:337	Mutation altering degron motif	0.6097
p.T328I	TCGA-55-8094	LUAD	TCGA	IIVYTE	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.2778
p.T328I	TCGA-55-8094	LUAD	TCGA	DIIVYTELP	CBL_PTK	329:337	Mutation rewiring degron network	0.3056
p.T328I	DO24150	LUAD	ICGC	IIVYTE	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.2778
p.T328I	DO24150	LUAD	ICGC	DIIVYTELP	CBL_PTK	329:337	Mutation rewiring degron network	0.3056
p.E335Q	TCGA-61-1901	OV	TCGA	IIVYTE	LIG_APCC_ABBA_1	330:335	Mutation altering degron motif	0.6744
p.E335Q	TCGA-61-1901	OV	TCGA	DIIVYTELP	CBL_PTK	329:337	Mutation altering degron motif	0.5633
p.E335Q	DO29378	OV	ICGC	IIVYTE	LIG_APCC_ABBA_1	330:335	Mutation altering degron motif	0.6744
p.E335Q	DO29378	OV	ICGC	DIIVYTELP	CBL_PTK	329:337	Mutation altering degron motif	0.5633
p.L336R	TCGA-A6-5665	COAD	TCGA	DIIVYTELP	CBL_PTK	329:337	Mutation altering degron motif	0.7316
p.L336R	DO9756	COAD	ICGC	DIIVYTELP	CBL_PTK	329:337	Mutation altering degron motif	0.7316
p.T334M	TCGA-AX-A3FT	UCEC	TCGA	IIVYTE	LIG_APCC_ABBA_1	330:335	Mutation altering degron motif	0.6312
p.T334M	TCGA-AX-A3FT	UCEC	TCGA	DIIVYTELP	CBL_PTK	329:337	Mutation altering degron motif	0.7423
p.T334M	DO40801	UCEC	ICGC	IIVYTE	LIG_APCC_ABBA_1	330:335	Mutation altering degron motif	0.6312
p.T334M	DO40801	UCEC	ICGC	DIIVYTELP	CBL_PTK	329:337	Mutation altering degron motif	0.7423
p.D329N	TCGA-D3-A2JF	SKCM	TCGA	DIIVYTELP	CBL_PTK	329:337	Mutation altering degron motif	0.5821
p.D329N	DO38153	SKCM	ICGC	DIIVYTELP	CBL_PTK	329:337	Mutation altering degron motif	0.5821
p.A339V	TCGA-EO-A3B0	UCEC	TCGA	IIVYTE	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.2222
p.A339V	TCGA-EO-A3B0	UCEC	TCGA	DIIVYTELP	CBL_PTK	329:337	Mutation rewiring degron network	0.2778
p.A339V	DO219773	UCEC	ICGC	IIVYTE	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.2222
p.A339V	DO219773	UCEC	ICGC	DIIVYTELP	CBL_PTK	329:337	Mutation rewiring degron network	0.2778
p.E340Q	TCGA-JW-A5VL	CESC	TCGA	IIVYTE	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.1944
p.E340Q	TCGA-JW-A5VL	CESC	TCGA	DIIVYTELP	CBL_PTK	329:337	Mutation rewiring degron network	0.25
p.E340Q	DO49976	CESC	ICGC	IIVYTE	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.1944
p.E340Q	DO49976	CESC	ICGC	DIIVYTELP	CBL_PTK	329:337	Mutation rewiring degron network	0.25
p.P337S	DO227745	COCA	ICGC	DIIVYTELP	CBL_PTK	329:337	Mutation altering degron motif	0.6752
p.P326L	DO223834	KIRC	ICGC	IIVYTE	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.2222
p.P326L	DO223834	KIRC	ICGC	DIIVYTELP	CBL_PTK	329:337	Mutation rewiring degron network	0.25
p.P322S	DO42793	UCEC	ICGC	IIVYTE	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.1111
p.P322S	DO42793	UCEC	ICGC	DIIVYTELP	CBL_PTK	329:337	Mutation rewiring degron network	0.1389
p.S320F	SIDM00875	Breast Carcinoma	GDSC	IIVYTE	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.0556
p.S320F	SIDM00875	Breast Carcinoma	GDSC	DIIVYTELP	CBL_PTK	329:337	Mutation rewiring degron network	0.0833
p.S320F	SIDM00309	Mesothelioma	GDSC	IIVYTE	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.0556
p.S320F	SIDM00309	Mesothelioma	GDSC	DIIVYTELP	CBL_PTK	329:337	Mutation rewiring degron network	0.0833
p.I330T	CAS-1	central nervous system	COSMIC	IIVYTE	LIG_APCC_ABBA_1	330:335	Mutation altering degron motif	0.7078
p.I330T	CAS-1	central nervous system	COSMIC	DIIVYTELP	CBL_PTK	329:337	Mutation altering degron motif	0.5966

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIR2DL3

UniProt ID: P43628

Entrez ID: 3804

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIR2DL3 in