DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
DIIVYTELP
Uniprot ID:
P43628
Source protein:
Killer cell immunoglobulin-like receptor 2DL3
Source gene:
KIR2DL3
Class:
CBL_PTK
Location:
329:337
E3 ligase:
CBL
DEGRON score:
0.9432
ASA_SCORE:
54.8667
COIL:
0.4816
CONS_SCORE:
0.3553
DSS_SCORE:
0.6793
HELIX:
0.0077
FCONS_SCORE:
1.22
RIG_SCORE:
0.8108
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P323S
TCGA-24-1562
OV
TCGA
DIIVYTELP
CBL_PTK
0.1667
p.P323S
DO28412
OV
ICGC
DIIVYTELP
CBL_PTK
0.1667
p.V332M
TCGA-2W-A8YY
CESC
TCGA
DIIVYTELP
CBL_PTK
0.6097
p.V332M
DO223732
CESC
ICGC
DIIVYTELP
CBL_PTK
0.6097
p.T328I
TCGA-55-8094
LUAD
TCGA
DIIVYTELP
CBL_PTK
0.3056
p.T328I
DO24150
LUAD
ICGC
DIIVYTELP
CBL_PTK
0.3056
p.E335Q
TCGA-61-1901
OV
TCGA
DIIVYTELP
CBL_PTK
0.5633
p.E335Q
DO29378
OV
ICGC
DIIVYTELP
CBL_PTK
0.5633
p.L336R
TCGA-A6-5665
COAD
TCGA
DIIVYTELP
CBL_PTK
0.7316
p.L336R
DO9756
COAD
ICGC
DIIVYTELP
CBL_PTK
0.7316
p.T334M
TCGA-AX-A3FT
UCEC
TCGA
DIIVYTELP
CBL_PTK
0.7423
p.T334M
DO40801
UCEC
ICGC
DIIVYTELP
CBL_PTK
0.7423
p.D329N
TCGA-D3-A2JF
SKCM
TCGA
DIIVYTELP
CBL_PTK
0.5821
p.D329N
DO38153
SKCM
ICGC
DIIVYTELP
CBL_PTK
0.5821
p.A339V
TCGA-EO-A3B0
UCEC
TCGA
DIIVYTELP
CBL_PTK
0.2778
p.A339V
DO219773
UCEC
ICGC
DIIVYTELP
CBL_PTK
0.2778
p.E340Q
TCGA-JW-A5VL
CESC
TCGA
DIIVYTELP
CBL_PTK
0.25
p.E340Q
DO49976
CESC
ICGC
DIIVYTELP
CBL_PTK
0.25
p.P337S
DO227745
COCA
ICGC
DIIVYTELP
CBL_PTK
0.6752
p.P326L
DO223834
KIRC
ICGC
DIIVYTELP
CBL_PTK
0.25
p.P322S
DO42793
UCEC
ICGC
DIIVYTELP
CBL_PTK
0.1389
p.S320F
SIDM00875
Breast Carcinoma
GDSC
DIIVYTELP
CBL_PTK
0.0833
p.S320F
SIDM00309
Mesothelioma
GDSC
DIIVYTELP
CBL_PTK
0.0833
p.I330T
CAS-1
central_nervous_system
COSMIC
DIIVYTELP
CBL_PTK
0.5966
Drug responses associated with KIR2DL3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DIIVYTELP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P43626
Killer cell immunoglobulin-like receptor 2DL1
CBL_PTK
328:336
DIIVYTELP
CBL
0.5501
More...
P43628
Killer cell immunoglobulin-like receptor 2DL3
CBL_PTK
329:337
DIIVYTELP
CBL
0.9432
More...