DegronMD

Uniprot ID: P43628

Source protein: Killer cell immunoglobulin-like receptor 2DL3

Source gene: KIR2DL3

Class: LIG_APCC_ABBA_1

Location: 330:335

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.892

ASA_SCORE: 50.0333

COIL: 0.3097

CONS_SCORE: 0.3756

DSS_SCORE: 0.6576

HELIX: 0.0062

FCONS_SCORE: 1.2952

RIG_SCORE: 0.837

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P323S	TCGA-24-1562	OV	TCGA	IIVYTE	LIG_APCC_ABBA_1	0.1389
p.P323S	DO28412	OV	ICGC	IIVYTE	LIG_APCC_ABBA_1	0.1389
p.V332M	TCGA-2W-A8YY	CESC	TCGA	IIVYTE	LIG_APCC_ABBA_1	0.6097
p.V332M	DO223732	CESC	ICGC	IIVYTE	LIG_APCC_ABBA_1	0.6097
p.T328I	TCGA-55-8094	LUAD	TCGA	IIVYTE	LIG_APCC_ABBA_1	0.2778
p.T328I	DO24150	LUAD	ICGC	IIVYTE	LIG_APCC_ABBA_1	0.2778
p.E335Q	TCGA-61-1901	OV	TCGA	IIVYTE	LIG_APCC_ABBA_1	0.6744
p.E335Q	DO29378	OV	ICGC	IIVYTE	LIG_APCC_ABBA_1	0.6744
p.T334M	TCGA-AX-A3FT	UCEC	TCGA	IIVYTE	LIG_APCC_ABBA_1	0.6312
p.T334M	DO40801	UCEC	ICGC	IIVYTE	LIG_APCC_ABBA_1	0.6312
p.A339V	TCGA-EO-A3B0	UCEC	TCGA	IIVYTE	LIG_APCC_ABBA_1	0.2222
p.A339V	DO219773	UCEC	ICGC	IIVYTE	LIG_APCC_ABBA_1	0.2222
p.E340Q	TCGA-JW-A5VL	CESC	TCGA	IIVYTE	LIG_APCC_ABBA_1	0.1944
p.E340Q	DO49976	CESC	ICGC	IIVYTE	LIG_APCC_ABBA_1	0.1944
p.P326L	DO223834	KIRC	ICGC	IIVYTE	LIG_APCC_ABBA_1	0.2222
p.P322S	DO42793	UCEC	ICGC	IIVYTE	LIG_APCC_ABBA_1	0.1111
p.S320F	SIDM00875	Breast Carcinoma	GDSC	IIVYTE	LIG_APCC_ABBA_1	0.0556
p.S320F	SIDM00309	Mesothelioma	GDSC	IIVYTE	LIG_APCC_ABBA_1	0.0556
p.I330T	CAS-1	central_nervous_system	COSMIC	IIVYTE	LIG_APCC_ABBA_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P43628	Killer cell immunoglobulin-like receptor 2DL3	LIG_APCC_ABBA_1	330:335	IIVYTE	APC,CDC20,FZR1	0.892	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons