DegronMD - P43629(KIR3DL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P436L	TCGA-50-6590	LUAD	TCGA	DTILYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.2222
p.D424E	TCGA-55-8094	LUAD	TCGA	DTILYTELP	CBL_PTK	424:432	Mutation altering degron motif	0.6758
p.S442F	TCGA-77-7141	LUSC	TCGA	DTILYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.0556
p.I426F	TCGA-95-7043	LUAD	TCGA	DTILYTELP	CBL_PTK	424:432	Mutation altering degron motif	0.6304
p.P418H	TCGA-AP-A059	UCEC	TCGA	DTILYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.1667
p.P421H	TCGA-BA-4076	HNSC	TCGA	DTILYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.25
p.R437I	DO219091	BLCA	ICGC	DTILYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.1944
p.E435K	DO49939	CESC	ICGC	DTILYTELP	CBL_PTK	424:432	Mutation substituting flanking lysine	0.3611
p.V423I	DO224735	COCA	ICGC	DTILYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.3056
p.L422P	DO229005	COCA	ICGC	DTILYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.2778
p.V427M	DO234419	ESAD	ICGC	DTILYTELP	CBL_PTK	424:432	Mutation altering degron motif	0.7208
p.V427M	DO13462	GBM	ICGC	DTILYTELP	CBL_PTK	424:432	Mutation altering degron motif	0.7208
p.P418T	DO11417	GBM	ICGC	DTILYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.1667
p.P414T	DO14606	HNSC	ICGC	DTILYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.0556
p.Q416L	DO228299	LICA	ICGC	DTILYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.1111
p.P419L	DO24692	LUAD	ICGC	DTILYTELP	CBL_PTK	424:432	Mutation substituting flanking lysine	0.3056
p.P419L	DO46850	RECA	ICGC	DTILYTELP	CBL_PTK	424:432	Mutation substituting flanking lysine	0.3056
p.S425F	DO26450	LUSC	ICGC	DTILYTELP	CBL_PTK	424:432	Mutation altering degron motif	0.7982
p.P427S	DO220851	MELA	ICGC	DTILYTELP	CBL_PTK	424:432	Mutation altering degron motif	0.6752
p.P427L	DO220851	MELA	ICGC	DTILYTELP	CBL_PTK	424:432	Mutation altering degron motif	0.7582
p.S438F	DO220890	MELA	ICGC	DTILYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.1667
p.E430K	DO37643	SKCM	ICGC	DTILYTELP	CBL_PTK	424:432	Mutation altering degron motif	0.591
p.P418L	DO37406	SKCM	ICGC	DTILYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.1667
p.R437K	DO51275	SKCM	ICGC	DTILYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.1944
p.T425I	DO41542	UCEC	ICGC	DTILYTELP	CBL_PTK	424:432	Mutation altering degron motif	0.5966
p.P422S	SIDM00545	Melanoma	GDSC	DTILYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.2778
p.P422S	ACH-000987	Skin Cancer	CCLE	DTILYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.2778
p.P422S	Mewo	skin	COSMIC	DTILYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.2778
p.K439N	SIDM01646	Non-Cancerous	GDSC	DTILYTELP	CBL_PTK	424:432	Mutation substituting flanking lysine	0.25
p.K439N	ACH-002358	Non-Cancerous	CCLE	DTILYTELP	CBL_PTK	424:432	Mutation substituting flanking lysine	0.25
p.V441F	SIDM01491	Colorectal Carcinoma	GDSC	DTILYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.0833
p.V441F	ACH-000342	Colon/Colorectal Cancer	CCLE	DTILYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.0833
p.I426S	ACH-001353	Pancreatic Cancer	CCLE	DTILYTELP	CBL_PTK	424:432	Mutation altering degron motif	0.623
p.I426S	ACH-002459	Skin Cancer	CCLE	DTILYTELP	CBL_PTK	424:432	Mutation altering degron motif	0.623
p.I426S	ACH-002460	Skin Cancer	CCLE	DTILYTELP	CBL_PTK	424:432	Mutation altering degron motif	0.623

Kaplan plot for KIR3DL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIR3DL1

UniProt ID: P43629

Entrez ID: 3811

Protein name: Killer cell immunoglobulin-like receptor 3DL1 (CD158 antigen-like family member E) (HLA-BW4-specific inhibitory NK cell receptor) (Natural killer-associated transcript 3) (NKAT-3) (p70 natural killer cell receptor clones CL-2/CL-11) (p70 NK receptor CL-2/CL-11) (CD antigen CD158e)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIR3DL1 in