DegronMD

Uniprot ID: P43629

Source protein: Killer cell immunoglobulin-like receptor 3DL1

Source gene: KIR3DL1

Class: CBL_PTK

Location: 424:432

E3 ligase: CBL

DEGRON score: 0.9562

ASA_SCORE: 50.5667

COIL: 0.4003

CONS_SCORE: 0.5857

DSS_SCORE: 0.6089

HELIX: 0.0079

FCONS_SCORE: 1.1136

RIG_SCORE: 0.7887

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P436L	TCGA-50-6590	LUAD	TCGA	DTILYTELP	CBL_PTK	0.2222
p.D424E	TCGA-55-8094	LUAD	TCGA	DTILYTELP	CBL_PTK	0.6758
p.S442F	TCGA-77-7141	LUSC	TCGA	DTILYTELP	CBL_PTK	0.0556
p.I426F	TCGA-95-7043	LUAD	TCGA	DTILYTELP	CBL_PTK	0.6304
p.P418H	TCGA-AP-A059	UCEC	TCGA	DTILYTELP	CBL_PTK	0.1667
p.P421H	TCGA-BA-4076	HNSC	TCGA	DTILYTELP	CBL_PTK	0.25
p.R437I	DO219091	BLCA	ICGC	DTILYTELP	CBL_PTK	0.1944
p.E435K	DO49939	CESC	ICGC	DTILYTELP	CBL_PTK	0.3611
p.V423I	DO224735	COCA	ICGC	DTILYTELP	CBL_PTK	0.3056
p.L422P	DO229005	COCA	ICGC	DTILYTELP	CBL_PTK	0.2778
p.V427M	DO234419	ESAD	ICGC	DTILYTELP	CBL_PTK	0.7208
p.V427M	DO13462	GBM	ICGC	DTILYTELP	CBL_PTK	0.7208
p.P418T	DO11417	GBM	ICGC	DTILYTELP	CBL_PTK	0.1667
p.P414T	DO14606	HNSC	ICGC	DTILYTELP	CBL_PTK	0.0556
p.Q416L	DO228299	LICA	ICGC	DTILYTELP	CBL_PTK	0.1111
p.P419L	DO24692	LUAD	ICGC	DTILYTELP	CBL_PTK	0.3056
p.P419L	DO46850	RECA	ICGC	DTILYTELP	CBL_PTK	0.3056
p.S425F	DO26450	LUSC	ICGC	DTILYTELP	CBL_PTK	0.7982
p.P427S	DO220851	MELA	ICGC	DTILYTELP	CBL_PTK	0.6752
p.P427L	DO220851	MELA	ICGC	DTILYTELP	CBL_PTK	0.7582
p.S438F	DO220890	MELA	ICGC	DTILYTELP	CBL_PTK	0.1667
p.E430K	DO37643	SKCM	ICGC	DTILYTELP	CBL_PTK	0.591
p.P418L	DO37406	SKCM	ICGC	DTILYTELP	CBL_PTK	0.1667
p.R437K	DO51275	SKCM	ICGC	DTILYTELP	CBL_PTK	0.1944
p.T425I	DO41542	UCEC	ICGC	DTILYTELP	CBL_PTK	0.5966
p.P422S	SIDM00545	Melanoma	GDSC	DTILYTELP	CBL_PTK	0.2778
p.P422S	ACH-000987	Skin Cancer	CCLE	DTILYTELP	CBL_PTK	0.2778
p.P422S	Mewo	skin	COSMIC	DTILYTELP	CBL_PTK	0.2778
p.K439N	SIDM01646	Non-Cancerous	GDSC	DTILYTELP	CBL_PTK	0.25
p.K439N	ACH-002358	Non-Cancerous	CCLE	DTILYTELP	CBL_PTK	0.25
p.V441F	SIDM01491	Colorectal Carcinoma	GDSC	DTILYTELP	CBL_PTK	0.0833
p.V441F	ACH-000342	Colon/Colorectal Cancer	CCLE	DTILYTELP	CBL_PTK	0.0833
p.I426S	ACH-001353	Pancreatic Cancer	CCLE	DTILYTELP	CBL_PTK	0.623
p.I426S	ACH-002459	Skin Cancer	CCLE	DTILYTELP	CBL_PTK	0.623
p.I426S	ACH-002460	Skin Cancer	CCLE	DTILYTELP	CBL_PTK	0.623

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DTILYTELP

Degron related mutations and impact score

Drug responses associated with KIR3DL1 mutations

All proteins holding degron of DTILYTELP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P43629	Killer cell immunoglobulin-like receptor 3DL1	CBL_PTK	424:432	DTILYTELP	CBL	0.9562	More...