DegronMD - P43630(KIR3DL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P418T	TCGA-14-3476	GBM	TCGA	DTSVYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.1667
p.V427M	TCGA-32-2616	GBM	TCGA	DTSVYTELP	CBL_PTK	424:432	Mutation altering degron motif	0.6097
p.T425I	TCGA-AJ-A3EL	UCEC	TCGA	DTSVYTELP	CBL_PTK	424:432	Mutation altering degron motif	0.5966
p.P414T	TCGA-CN-6992	HNSC	TCGA	DTSVYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.0556
p.E430K	TCGA-EE-A2GH	SKCM	TCGA	DTSVYTELP	CBL_PTK	424:432	Mutation altering degron motif	0.591
p.E435K	TCGA-EK-A2PG	CESC	TCGA	DTSVYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.25
p.P418L	TCGA-FW-A3R5	SKCM	TCGA	DTSVYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.1667
p.R437K	TCGA-W3-AA1R	SKCM	TCGA	DTSVYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.1944
p.R437I	TCGA-ZF-AA4X	BLCA	TCGA	DTSVYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.1944
p.R420I	DO219091	BLCA	ICGC	DTSVYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.2222
p.E418K	DO49939	CESC	ICGC	DTSVYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.1667
p.L434I	DO10172	COAD	ICGC	DTSVYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.2778
p.G436W	DO227745	COCA	ICGC	DTSVYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.2222
p.A429S	DO233871	GACA	ICGC	DTSVYTELP	CBL_PTK	424:432	Mutation altering degron motif	0.7588
p.E435Q	DO14218	HNSC	ICGC	DTSVYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.25
p.S421F	DO220890	MELA	ICGC	DTSVYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.25
p.G436E	DO229462	SKCA	ICGC	DTSVYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.2222
p.L434F	DO37679	SKCM	ICGC	DTSVYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.2778
p.R420K	DO51275	SKCM	ICGC	DTSVYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.2222
p.V437I	DO231475	THCA	ICGC	DTSVYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.1944
p.T423I	SIDM00660	Colorectal Carcinoma	GDSC	DTSVYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.3056
p.T423I	ACH-000985	Colon/Colorectal Cancer	CCLE	DTSVYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.3056
p.T423I	LS-411N	large intestine	COSMIC	DTSVYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.3056
p.P436S	SIDM00230	Small Cell Lung Carcinoma	GDSC	DTSVYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.2222
p.P436S	ACH-002145	Lung Cancer	CCLE	DTSVYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.2222
p.P436S	IST-SL2	lung	COSMIC	DTSVYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.2222
p.K439Q	SIDM00251	Gastric Carcinoma	GDSC	DTSVYTELP	CBL_PTK	424:432	Mutation substituting flanking lysine	0.25
p.K439Q	SIDM01257	Hepatocellular Carcinoma	GDSC	DTSVYTELP	CBL_PTK	424:432	Mutation substituting flanking lysine	0.25
p.K439Q	SIDM00062	Hepatocellular Carcinoma	GDSC	DTSVYTELP	CBL_PTK	424:432	Mutation substituting flanking lysine	0.25
p.T429M	SIDM00493	Other Solid Cancers	GDSC	DTSVYTELP	CBL_PTK	424:432	Mutation altering degron motif	0.7423
p.T429M	ACH-001075	Lung Cancer	CCLE	DTSVYTELP	CBL_PTK	424:432	Mutation altering degron motif	0.7423
p.T429M	NCI-H292	lung	COSMIC	DTSVYTELP	CBL_PTK	424:432	Mutation altering degron motif	0.7423
p.R417M	ACH-000868	Lung Cancer	CCLE	DTSVYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.1389
p.E435A	LU-165	lung	COSMIC	DTSVYTELP	CBL_PTK	424:432	Mutation rewiring degron network	0.25
p.C426F	KS-1	central nervous system	COSMIC	DTSVYTELP	CBL_PTK	424:432	Mutation altering degron motif	0.7108
p.P419S	IST-SL2	lung	COSMIC	DTSVYTELP	CBL_PTK	424:432	Mutation substituting flanking lysine	0.3056

Kaplan plot for KIR3DL2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIR3DL2

UniProt ID: P43630

Entrez ID: 3812

Protein name: Killer cell immunoglobulin-like receptor 3DL2 (CD158 antigen-like family member K) (Natural killer-associated transcript 4) (NKAT-4) (p70 natural killer cell receptor clone CL-5) (p70 NK receptor CL-5) (CD antigen CD158k)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIR3DL2 in