DegronMD

Uniprot ID: P43630

Source protein: Killer cell immunoglobulin-like receptor 3DL2

Source gene: KIR3DL2

Class: CBL_PTK

Location: 424:432

E3 ligase: CBL

DEGRON score: 0.7437

ASA_SCORE: 62.7222

COIL: 0.5733

CONS_SCORE: 0.5222

DSS_SCORE: 0.5516

HELIX: 0.0153

FCONS_SCORE: 1.0606

RIG_SCORE: 0.741

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P418T	TCGA-14-3476	GBM	TCGA	DTSVYTELP	CBL_PTK	0.1667
p.V427M	TCGA-32-2616	GBM	TCGA	DTSVYTELP	CBL_PTK	0.6097
p.T425I	TCGA-AJ-A3EL	UCEC	TCGA	DTSVYTELP	CBL_PTK	0.5966
p.P414T	TCGA-CN-6992	HNSC	TCGA	DTSVYTELP	CBL_PTK	0.0556
p.E430K	TCGA-EE-A2GH	SKCM	TCGA	DTSVYTELP	CBL_PTK	0.591
p.E435K	TCGA-EK-A2PG	CESC	TCGA	DTSVYTELP	CBL_PTK	0.25
p.P418L	TCGA-FW-A3R5	SKCM	TCGA	DTSVYTELP	CBL_PTK	0.1667
p.R437K	TCGA-W3-AA1R	SKCM	TCGA	DTSVYTELP	CBL_PTK	0.1944
p.R437I	TCGA-ZF-AA4X	BLCA	TCGA	DTSVYTELP	CBL_PTK	0.1944
p.R420I	DO219091	BLCA	ICGC	DTSVYTELP	CBL_PTK	0.2222
p.E418K	DO49939	CESC	ICGC	DTSVYTELP	CBL_PTK	0.1667
p.L434I	DO10172	COAD	ICGC	DTSVYTELP	CBL_PTK	0.2778
p.G436W	DO227745	COCA	ICGC	DTSVYTELP	CBL_PTK	0.2222
p.A429S	DO233871	GACA	ICGC	DTSVYTELP	CBL_PTK	0.7588
p.E435Q	DO14218	HNSC	ICGC	DTSVYTELP	CBL_PTK	0.25
p.S421F	DO220890	MELA	ICGC	DTSVYTELP	CBL_PTK	0.25
p.G436E	DO229462	SKCA	ICGC	DTSVYTELP	CBL_PTK	0.2222
p.L434F	DO37679	SKCM	ICGC	DTSVYTELP	CBL_PTK	0.2778
p.R420K	DO51275	SKCM	ICGC	DTSVYTELP	CBL_PTK	0.2222
p.V437I	DO231475	THCA	ICGC	DTSVYTELP	CBL_PTK	0.1944
p.T423I	SIDM00660	Colorectal Carcinoma	GDSC	DTSVYTELP	CBL_PTK	0.3056
p.T423I	ACH-000985	Colon/Colorectal Cancer	CCLE	DTSVYTELP	CBL_PTK	0.3056
p.T423I	LS-411N	large_intestine	COSMIC	DTSVYTELP	CBL_PTK	0.3056
p.P436S	SIDM00230	Small Cell Lung Carcinoma	GDSC	DTSVYTELP	CBL_PTK	0.2222
p.P436S	ACH-002145	Lung Cancer	CCLE	DTSVYTELP	CBL_PTK	0.2222
p.P436S	IST-SL2	lung	COSMIC	DTSVYTELP	CBL_PTK	0.2222
p.K439Q	SIDM00251	Gastric Carcinoma	GDSC	DTSVYTELP	CBL_PTK	0.25
p.K439Q	SIDM01257	Hepatocellular Carcinoma	GDSC	DTSVYTELP	CBL_PTK	0.25
p.K439Q	SIDM00062	Hepatocellular Carcinoma	GDSC	DTSVYTELP	CBL_PTK	0.25
p.T429M	SIDM00493	Other Solid Cancers	GDSC	DTSVYTELP	CBL_PTK	0.7423
p.T429M	ACH-001075	Lung Cancer	CCLE	DTSVYTELP	CBL_PTK	0.7423
p.T429M	NCI-H292	lung	COSMIC	DTSVYTELP	CBL_PTK	0.7423
p.R417M	ACH-000868	Lung Cancer	CCLE	DTSVYTELP	CBL_PTK	0.1389
p.E435A	LU-165	lung	COSMIC	DTSVYTELP	CBL_PTK	0.25
p.C426F	KS-1	central_nervous_system	COSMIC	DTSVYTELP	CBL_PTK	0.7108
p.P419S	IST-SL2	lung	COSMIC	DTSVYTELP	CBL_PTK	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DTSVYTELP

Degron related mutations and impact score

Drug responses associated with KIR3DL2 mutations

All proteins holding degron of DTSVYTELP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P43630	Killer cell immunoglobulin-like receptor 3DL2	CBL_PTK	424:432	DTSVYTELP	CBL	0.7437	More...