DegronMD - P46087(NOP2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A662T	TCGA-VQ-A8PP	STAD	TCGA	DSELSTVPSV	DEG_COP1_1	658:667	Mutation altering degron motif	0.7139
p.T659I	DO51734	COAD	ICGC	DSELSTVPSV	DEG_COP1_1	658:667	Mutation altering degron motif	0.7078
p.T664K	DO229015	LICA	ICGC	DSELSTVPSV	DEG_COP1_1	658:667	Mutation altering degron motif	0.7306
p.S662F	DO26526	LUSC	ICGC	DSELSTVPSV	DEG_COP1_1	658:667	Mutation altering degron motif	0.6871
p.S650Y	DO41361	UCEC	ICGC	DSELSTVPSV	DEG_COP1_1	658:667	Mutation rewiring degron network	0.1111
p.S652N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSELSTVPSV	DEG_COP1_1	658:667	Mutation rewiring degron network	0.1667
p.S652N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DSELSTVPSV	DEG_COP1_1	658:667	Mutation rewiring degron network	0.1667
p.K660R	SIDM01160	Bladder Carcinoma	GDSC	DSELSTVPSV	DEG_COP1_1	658:667	Mutation altering degron motif	0.7237
p.S653R	SIDM01709	Melanoma	GDSC	DSELSTVPSV	DEG_COP1_1	658:667	Mutation rewiring degron network	0.1944
p.I653V	ACH-000189	Kidney Cancer	CCLE	DSELSTVPSV	DEG_COP1_1	658:667	Mutation rewiring degron network	0.1944
p.I653V	RCC10RGB	kidney	COSMIC	DSELSTVPSV	DEG_COP1_1	658:667	Mutation rewiring degron network	0.1944
p.A657V	ACH-002222	Leukemia	CCLE	DSELSTVPSV	DEG_COP1_1	658:667	Mutation rewiring degron network	0.3056
p.A657V	CTV-1	haematopoietic and lymphoid tissue	COSMIC	DSELSTVPSV	DEG_COP1_1	658:667	Mutation rewiring degron network	0.3056
p.A653V	CTV-1	haematopoietic and lymphoid tissue	COSMIC	DSELSTVPSV	DEG_COP1_1	658:667	Mutation rewiring degron network	0.1944
p.I649V	RCC10RGB	kidney	COSMIC	DSELSTVPSV	DEG_COP1_1	658:667	Mutation substituting flanking lysine	0.1944

Kaplan plot for NOP2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NOP2

UniProt ID: P46087

Entrez ID: 4839

Protein name: Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for NOP2 in