DegronMD

Uniprot ID: P46087

Source protein: Probable 28S rRNA

Source gene: NOP2

Class: DEG_COP1_1

Location: 658:667

E3 ligase: COP1

DEGRON score: 0.9339

ASA_SCORE: 87.4

COIL: 0.8737

CONS_SCORE: 0.2597

DSS_SCORE: 0.5463

HELIX: 0.0939

FCONS_SCORE: 0.9755

RIG_SCORE: 0.6753

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A662T	TCGA-VQ-A8PP	STAD	TCGA	DSELSTVPSV	DEG_COP1_1	0.7139
p.T659I	DO51734	COAD	ICGC	DSELSTVPSV	DEG_COP1_1	0.7078
p.T664K	DO229015	LICA	ICGC	DSELSTVPSV	DEG_COP1_1	0.7306
p.S662F	DO26526	LUSC	ICGC	DSELSTVPSV	DEG_COP1_1	0.6871
p.S650Y	DO41361	UCEC	ICGC	DSELSTVPSV	DEG_COP1_1	0.1111
p.S652N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSELSTVPSV	DEG_COP1_1	0.1667
p.S652N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DSELSTVPSV	DEG_COP1_1	0.1667
p.K660R	SIDM01160	Bladder Carcinoma	GDSC	DSELSTVPSV	DEG_COP1_1	0.7237
p.S653R	SIDM01709	Melanoma	GDSC	DSELSTVPSV	DEG_COP1_1	0.1944
p.I653V	ACH-000189	Kidney Cancer	CCLE	DSELSTVPSV	DEG_COP1_1	0.1944
p.I653V	RCC10RGB	kidney	COSMIC	DSELSTVPSV	DEG_COP1_1	0.1944
p.A657V	ACH-002222	Leukemia	CCLE	DSELSTVPSV	DEG_COP1_1	0.3056
p.A657V	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSELSTVPSV	DEG_COP1_1	0.3056
p.A653V	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSELSTVPSV	DEG_COP1_1	0.1944
p.I649V	RCC10RGB	kidney	COSMIC	DSELSTVPSV	DEG_COP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46087	Probable 28S rRNA	DEG_COP1_1	658:667	DSELSTVPSV	COP1	0.9339	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons