DegronMD - P46093(GPR4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M316V	TCGA-59-2363	OV	TCGA	LETPLTS	DEG_SCF_FBW7_1	323:329	Mutation rewiring degron network	0.1389
p.M316V	DO29730	OV	ICGC	LETPLTS	DEG_SCF_FBW7_1	323:329	Mutation rewiring degron network	0.1389
p.K336N	TCGA-BS-A0UF	UCEC	TCGA	LETPLTS	DEG_SCF_FBW7_1	323:329	Mutation substituting flanking lysine	0.25
p.K336N	DO41488	UCEC	ICGC	LETPLTS	DEG_SCF_FBW7_1	323:329	Mutation substituting flanking lysine	0.25
p.A335T	TCGA-D3-A8GI	SKCM	TCGA	LETPLTS	DEG_SCF_FBW7_1	323:329	Mutation rewiring degron network	0.1667
p.A335T	DO50284	SKCM	ICGC	LETPLTS	DEG_SCF_FBW7_1	323:329	Mutation rewiring degron network	0.1667
p.A317D	DO229028	LICA	ICGC	LETPLTS	DEG_SCF_FBW7_1	323:329	Mutation rewiring degron network	0.1667
p.L327I	DO229037	LICA	ICGC	LETPLTS	DEG_SCF_FBW7_1	323:329	Mutation altering degron motif	0.6063
p.T322N	DO229006	LICA	ICGC	LETPLTS	DEG_SCF_FBW7_1	323:329	Mutation rewiring degron network	0.3056
p.N332D	DO232224	PBCA	ICGC	LETPLTS	DEG_SCF_FBW7_1	323:329	Mutation rewiring degron network	0.25
p.L321F	DO229268	THCA	ICGC	LETPLTS	DEG_SCF_FBW7_1	323:329	Mutation rewiring degron network	0.2778
p.A335P	SIDM01004	Chronic Myelogenous Leukemia	GDSC	LETPLTS	DEG_SCF_FBW7_1	323:329	Mutation rewiring degron network	0.1667
p.A335P	ACH-000983	Leukemia	CCLE	LETPLTS	DEG_SCF_FBW7_1	323:329	Mutation rewiring degron network	0.1667
p.A335P	KCL-22	haematopoietic and lymphoid tissue	COSMIC	LETPLTS	DEG_SCF_FBW7_1	323:329	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons