DegronMD

Uniprot ID: P46093

Source protein: G-protein coupled receptor 4

Source gene: GPR4

Class: DEG_SCF_FBW7_1

Location: 323:329

E3 ligase: FBXW7

DEGRON score: 0.9701

ASA_SCORE: 105.5429

COIL: 0.8246

CONS_SCORE: 0.6524

DSS_SCORE: 0.5232

HELIX: 0.0323

FCONS_SCORE: 1.5115

RIG_SCORE: 0.7464

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M316V	TCGA-59-2363	OV	TCGA	LETPLTS	DEG_SCF_FBW7_1	0.1389
p.M316V	DO29730	OV	ICGC	LETPLTS	DEG_SCF_FBW7_1	0.1389
p.K336N	TCGA-BS-A0UF	UCEC	TCGA	LETPLTS	DEG_SCF_FBW7_1	0.25
p.K336N	DO41488	UCEC	ICGC	LETPLTS	DEG_SCF_FBW7_1	0.25
p.A335T	TCGA-D3-A8GI	SKCM	TCGA	LETPLTS	DEG_SCF_FBW7_1	0.1667
p.A335T	DO50284	SKCM	ICGC	LETPLTS	DEG_SCF_FBW7_1	0.1667
p.A317D	DO229028	LICA	ICGC	LETPLTS	DEG_SCF_FBW7_1	0.1667
p.L327I	DO229037	LICA	ICGC	LETPLTS	DEG_SCF_FBW7_1	0.6063
p.T322N	DO229006	LICA	ICGC	LETPLTS	DEG_SCF_FBW7_1	0.3056
p.N332D	DO232224	PBCA	ICGC	LETPLTS	DEG_SCF_FBW7_1	0.25
p.L321F	DO229268	THCA	ICGC	LETPLTS	DEG_SCF_FBW7_1	0.2778
p.A335P	SIDM01004	Chronic Myelogenous Leukemia	GDSC	LETPLTS	DEG_SCF_FBW7_1	0.1667
p.A335P	ACH-000983	Leukemia	CCLE	LETPLTS	DEG_SCF_FBW7_1	0.1667
p.A335P	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	LETPLTS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46093	G-protein coupled receptor 4	DEG_SCF_FBW7_1	323:329	LETPLTS	FBXW7	0.9701	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons