DegronMD - P46459(NSF)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P545S	TCGA-CF-A9FF	BLCA	TCGA	DRTPLVSVL	DEG_APCC_DBOX_1	532:540	Mutation rewiring degron network	0.1944
p.R533H	TCGA-D5-6930	COAD	TCGA	DRTPLVSVL	DEG_APCC_DBOX_1	532:540	Mutation altering degron motif	0.8244
p.V534I	DO51972	CLLE	ICGC	DRTPLVSVL	DEG_APCC_DBOX_1	532:540	Mutation altering degron motif	0.7076
p.V534I	DO45461	LUSC	ICGC	DRTPLVSVL	DEG_APCC_DBOX_1	532:540	Mutation altering degron motif	0.7076
p.V534I	DO40996	UCEC	ICGC	DRTPLVSVL	DEG_APCC_DBOX_1	532:540	Mutation altering degron motif	0.7076
p.V534I	DO41903	UCEC	ICGC	DRTPLVSVL	DEG_APCC_DBOX_1	532:540	Mutation altering degron motif	0.7076
p.K545N	DO7934	COAD	ICGC	DRTPLVSVL	DEG_APCC_DBOX_1	532:540	Mutation rewiring degron network	0.1944
p.P541L	DO48558	LIHC	ICGC	DRTPLVSVL	DEG_APCC_DBOX_1	532:540	Mutation rewiring degron network	0.3056
p.G550W	DO37738	SKCM	ICGC	DRTPLVSVL	DEG_APCC_DBOX_1	532:540	Mutation rewiring degron network	0.0556
p.L536P	DO229259	THCA	ICGC	DRTPLVSVL	DEG_APCC_DBOX_1	532:540	Mutation altering degron motif	0.7582
p.A539T	DO229232	THCA	ICGC	DRTPLVSVL	DEG_APCC_DBOX_1	532:540	Mutation altering degron motif	0.7139
p.L527I	DO43041	UCEC	ICGC	DRTPLVSVL	DEG_APCC_DBOX_1	532:540	Mutation rewiring degron network	0.1944
p.R533P	SIDM00260	Gastric Carcinoma	GDSC	DRTPLVSVL	DEG_APCC_DBOX_1	532:540	Mutation altering degron motif	0.7512
p.R533P	ACH-002161	Gastric Cancer	CCLE	DRTPLVSVL	DEG_APCC_DBOX_1	532:540	Mutation altering degron motif	0.7512
p.R533P	MKN28	stomach	COSMIC	DRTPLVSVL	DEG_APCC_DBOX_1	532:540	Mutation altering degron motif	0.7512
p.T528P	SIDM00168	Head and Neck Carcinoma	GDSC	DRTPLVSVL	DEG_APCC_DBOX_1	532:540	Mutation rewiring degron network	0.2222
p.R528P	MKN28	stomach	COSMIC	DRTPLVSVL	DEG_APCC_DBOX_1	532:540	Mutation rewiring degron network	0.2222

Kaplan plot for NSF in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NSF

UniProt ID: P46459

Entrez ID: 4905

Protein name: Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NSF in