DegronMD

Uniprot ID: P46459

Source protein: Vesicle-fusing ATPase

Source gene: NSF

Class: DEG_APCC_DBOX_1

Location: 532:540

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9379

ASA_SCORE: 47.4889

COIL: 0.5781

CONS_SCORE: 0.4507

DSS_SCORE: 0.4694

HELIX: 0.0086

FCONS_SCORE: 0.8377

RIG_SCORE: 0.7732

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R533H	TCGA-D5-6930	COAD	TCGA	DRTPLVSVL	DEG_APCC_DBOX_1	0.8244
p.L536P	DO229259	THCA	ICGC	DRTPLVSVL	DEG_APCC_DBOX_1	0.7582
p.R533P	SIDM00260	Gastric Carcinoma	GDSC	DRTPLVSVL	DEG_APCC_DBOX_1	0.7512
p.R533P	ACH-002161	Gastric Cancer	CCLE	DRTPLVSVL	DEG_APCC_DBOX_1	0.7512
p.R533P	MKN28	stomach	COSMIC	DRTPLVSVL	DEG_APCC_DBOX_1	0.7512
p.A539T	DO229232	THCA	ICGC	DRTPLVSVL	DEG_APCC_DBOX_1	0.7139
p.V534I	DO51972	CLLE	ICGC	DRTPLVSVL	DEG_APCC_DBOX_1	0.7076
p.V534I	DO45461	LUSC	ICGC	DRTPLVSVL	DEG_APCC_DBOX_1	0.7076
p.V534I	DO40996	UCEC	ICGC	DRTPLVSVL	DEG_APCC_DBOX_1	0.7076
p.V534I	DO41903	UCEC	ICGC	DRTPLVSVL	DEG_APCC_DBOX_1	0.7076
p.P541L	DO48558	LIHC	ICGC	DRTPLVSVL	DEG_APCC_DBOX_1	0.3056
p.T528P	SIDM00168	Head and Neck Carcinoma	GDSC	DRTPLVSVL	DEG_APCC_DBOX_1	0.2222
p.R528P	MKN28	stomach	COSMIC	DRTPLVSVL	DEG_APCC_DBOX_1	0.2222
p.P545S	TCGA-CF-A9FF	BLCA	TCGA	DRTPLVSVL	DEG_APCC_DBOX_1	0.1944
p.K545N	DO7934	COAD	ICGC	DRTPLVSVL	DEG_APCC_DBOX_1	0.1944
p.L527I	DO43041	UCEC	ICGC	DRTPLVSVL	DEG_APCC_DBOX_1	0.1944
p.G550W	DO37738	SKCM	ICGC	DRTPLVSVL	DEG_APCC_DBOX_1	0.0556

Showing 1 to 17 of 17 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46459	Vesicle-fusing ATPase	DEG_APCC_DBOX_1	532:540	DRTPLVSVL	APC,CDC20,FZR1	0.9379	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons