DegronMD - P46527(CDKN1B)

GO - Biological processes (BP): autophagic cell death [GO:0048102]; cellular response to antibiotic [GO:0071236]; cellular response to lithium ion [GO:0071285]; cellular response to organic cyclic compound [GO:0071407]; cellular senescence [GO:0090398]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; heart development [GO:0007507]; inner ear development [GO:0048839]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiac muscle tissue regeneration [GO:1905179]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cellular component movement [GO:0051271]; negative regulation of cyclin-dependent protein kinase activity [GO:1904030]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; negative regulation of kinase activity [GO:0033673]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of phosphorylation [GO:0042326]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; Notch signaling pathway [GO:0007219]; placenta development [GO:0001890]; positive regulation of cell death [GO:0010942]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of protein catabolic process [GO:0045732]; potassium ion transport [GO:0006813]; regulation of cell cycle [GO:0051726]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of exit from mitosis [GO:0007096]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of lens fiber cell differentiation [GO:1902746]; response to amino acid [GO:0043200]; response to cadmium ion [GO:0046686]; response to estradiol [GO:0032355]; response to glucose [GO:0009749]; response to hypoxia [GO:0001666]; response to peptide hormone [GO:0043434]; response to xenobiotic stimulus [GO:0009410]; sensory perception of sound [GO:0007605] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P191H	TCGA-AP-A051	UCEC	TCGA	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.3056
p.P191H	DO42673	UCEC	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.3056
p.V184M	DO48424	BLCA	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation altering degron motif	0.6097
p.I173N	DO9410	COAD	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.0556
p.I200L	DO9876	COAD	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.0556
p.T185I	DO233882	GACA	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation altering degron motif	0.7078
p.F181L	DO14566	HNSC	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.2778
p.F181L	DO45211	LIRI	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.2778
p.G192V	DO228974	LICA	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.2778
p.G182C	DO229022	LICA	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.3056
p.G177V	DO229027	LICA	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.1667
p.A179S	DO229035	LICA	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.2222
p.A179S	DO229038	LICA	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.2222
p.N196S	DO26834	LUSC	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.1667
p.S178F	DO228343	MALY	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation blocking phosphorylation signal	0.6389
p.K199N	DO223286	UCEC	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.0833
p.K199N	ACH-000991	Colon/Colorectal Cancer	CCLE	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.0833
p.K199N	SNU-81	large intestine	COSMIC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.0833
p.N197I	DO41235	UCEC	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.1389
p.L193F	SIDM00855	Other Sarcomas	GDSC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.25
p.L193F	SIDM00694	Other Solid Cancers	GDSC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.25
p.L193F	SIDM00878	Breast Carcinoma	GDSC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.25
p.L193F	SIDM00849	Kidney Carcinoma	GDSC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.25
p.L193F	SIDM00431	T-Lymphoblastic Leukemia	GDSC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.25
p.L193F	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.25
p.L193F	SIDM01173	Rhabdomyosarcoma	GDSC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.25
p.G177S	SIDM00041	Gastric Carcinoma	GDSC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.1667
p.G177S	ACH-002306	Gastric Cancer	CCLE	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.1667
p.G177S	STS-0421	soft tissue	COSMIC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.1667
p.N196I	ACH-000864	Endometrial/Uterine Cancer	CCLE	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.1667
p.N196I	COLO-684	endometrium	COSMIC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	183:190	Mutation rewiring degron network	0.1667

Kaplan plot for CDKN1B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDKN1B

UniProt ID: P46527

Entrez ID: 1027

Protein name: Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDKN1B in