DegronMD

Uniprot ID: P46527

Source protein: Cyclin-dependent kinase inhibitor 1B

Source gene: CDKN1B

Class: DEG_SCF_SKP2-CKS1_1

Location: 183:190

E3 ligase: SKP2,CSK1

DEGRON score: 0.9325

ASA_SCORE: 93.675

COIL: 0.8121

CONS_SCORE: 0.4598

DSS_SCORE: 0.8411

HELIX: 0.023

FCONS_SCORE: 0.9992

RIG_SCORE: 0.6256

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P191H	TCGA-AP-A051	UCEC	TCGA	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.3056
p.P191H	DO42673	UCEC	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.3056
p.V184M	DO48424	BLCA	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.6097
p.I173N	DO9410	COAD	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.0556
p.I200L	DO9876	COAD	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.0556
p.T185I	DO233882	GACA	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.7078
p.F181L	DO14566	HNSC	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.2778
p.F181L	DO45211	LIRI	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.2778
p.G192V	DO228974	LICA	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.2778
p.G182C	DO229022	LICA	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.3056
p.G177V	DO229027	LICA	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.1667
p.A179S	DO229035	LICA	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.2222
p.A179S	DO229038	LICA	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.2222
p.N196S	DO26834	LUSC	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.1667
p.S178F	DO228343	MALY	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.6389
p.K199N	DO223286	UCEC	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.0833
p.K199N	ACH-000991	Colon/Colorectal Cancer	CCLE	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.0833
p.K199N	SNU-81	large_intestine	COSMIC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.0833
p.N197I	DO41235	UCEC	ICGC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.1389
p.L193F	SIDM00855	Other Sarcomas	GDSC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.25
p.L193F	SIDM00694	Other Solid Cancers	GDSC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.25
p.L193F	SIDM00878	Breast Carcinoma	GDSC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.25
p.L193F	SIDM00849	Kidney Carcinoma	GDSC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.25
p.L193F	SIDM00431	T-Lymphoblastic Leukemia	GDSC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.25
p.L193F	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.25
p.L193F	SIDM01173	Rhabdomyosarcoma	GDSC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.25
p.G177S	SIDM00041	Gastric Carcinoma	GDSC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.1667
p.G177S	ACH-002306	Gastric Cancer	CCLE	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.1667
p.G177S	STS-0421	soft_tissue	COSMIC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.1667
p.N196I	ACH-000864	Endometrial/Uterine Cancer	CCLE	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.1667
p.N196I	COLO-684	endometrium	COSMIC	SVEQTPKK	DEG_SCF_SKP2-CKS1_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SVEQTPKK

Degron related mutations and impact score

Drug responses associated with CDKN1B mutations

All proteins holding degron of SVEQTPKK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46527	Cyclin-dependent kinase inhibitor 1B	DEG_SCF_SKP2-CKS1_1	183:190	SVEQTPKK	SKP2,CSK1	0.9325	More...