DegronMD - P46778(RPL21)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K115N	TCGA-B5-A1MR	UCEC	TCGA	VKEND	DEG_APCC_KENBOX_2	109:113	Mutation rewiring degron network	0.2778
p.K115N	DO41758	UCEC	ICGC	VKEND	DEG_APCC_KENBOX_2	109:113	Mutation rewiring degron network	0.2778
p.R108C	TCGA-B5-A3FA	UCEC	TCGA	VKEND	DEG_APCC_KENBOX_2	109:113	Mutation rewiring degron network	0.3056
p.R108C	DO52402	UCEC	ICGC	VKEND	DEG_APCC_KENBOX_2	109:113	Mutation rewiring degron network	0.3056
p.A119T	TCGA-FI-A2D5	UCEC	TCGA	VKEND	DEG_APCC_KENBOX_2	109:113	Mutation rewiring degron network	0.1667
p.A119T	DO41331	UCEC	ICGC	VKEND	DEG_APCC_KENBOX_2	109:113	Mutation rewiring degron network	0.1667
p.E121Q	DO230950	LUSC	ICGC	VKEND	DEG_APCC_KENBOX_2	109:113	Mutation rewiring degron network	0.1111
p.E121Q	DO224638	LUSC	ICGC	VKEND	DEG_APCC_KENBOX_2	109:113	Mutation rewiring degron network	0.1111
p.R102Q	DO229253	THCA	ICGC	VKEND	DEG_APCC_KENBOX_2	109:113	Mutation rewiring degron network	0.1389
p.R102Q	DO229229	THCA	ICGC	VKEND	DEG_APCC_KENBOX_2	109:113	Mutation rewiring degron network	0.1389
p.R102Q	DO229248	THCA	ICGC	VKEND	DEG_APCC_KENBOX_2	109:113	Mutation rewiring degron network	0.1389
p.R102Q	DO229245	THCA	ICGC	VKEND	DEG_APCC_KENBOX_2	109:113	Mutation rewiring degron network	0.1389
p.E118K	SIDM00516	Melanoma	GDSC	VKEND	DEG_APCC_KENBOX_2	109:113	Mutation rewiring degron network	0.1944
p.E118K	ACH-002166	Skin Cancer	CCLE	VKEND	DEG_APCC_KENBOX_2	109:113	Mutation rewiring degron network	0.1944
p.E118K	MZ7-mel	skin	COSMIC	VKEND	DEG_APCC_KENBOX_2	109:113	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons