DegronMD

Uniprot ID: P46778

Source protein: 60S ribosomal protein L21

Source gene: RPL21

Class: DEG_APCC_KENBOX_2

Location: 109:113

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5218

ASA_SCORE: 87.98

COIL: 0.2636

CONS_SCORE: 0.5329

DSS_SCORE: 0.5694

HELIX: 0.7312

FCONS_SCORE: 0.9827

RIG_SCORE: 0.7159

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K115N	TCGA-B5-A1MR	UCEC	TCGA	VKEND	DEG_APCC_KENBOX_2	0.2778
p.K115N	DO41758	UCEC	ICGC	VKEND	DEG_APCC_KENBOX_2	0.2778
p.R108C	TCGA-B5-A3FA	UCEC	TCGA	VKEND	DEG_APCC_KENBOX_2	0.3056
p.R108C	DO52402	UCEC	ICGC	VKEND	DEG_APCC_KENBOX_2	0.3056
p.A119T	TCGA-FI-A2D5	UCEC	TCGA	VKEND	DEG_APCC_KENBOX_2	0.1667
p.A119T	DO41331	UCEC	ICGC	VKEND	DEG_APCC_KENBOX_2	0.1667
p.E121Q	DO230950	LUSC	ICGC	VKEND	DEG_APCC_KENBOX_2	0.1111
p.E121Q	DO224638	LUSC	ICGC	VKEND	DEG_APCC_KENBOX_2	0.1111
p.R102Q	DO229253	THCA	ICGC	VKEND	DEG_APCC_KENBOX_2	0.1389
p.R102Q	DO229229	THCA	ICGC	VKEND	DEG_APCC_KENBOX_2	0.1389
p.R102Q	DO229248	THCA	ICGC	VKEND	DEG_APCC_KENBOX_2	0.1389
p.R102Q	DO229245	THCA	ICGC	VKEND	DEG_APCC_KENBOX_2	0.1389
p.E118K	SIDM00516	Melanoma	GDSC	VKEND	DEG_APCC_KENBOX_2	0.1944
p.E118K	ACH-002166	Skin Cancer	CCLE	VKEND	DEG_APCC_KENBOX_2	0.1944
p.E118K	MZ7-mel	skin	COSMIC	VKEND	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46778	60S ribosomal protein L21	DEG_APCC_KENBOX_2	109:113	VKEND	APC,CDC20,FZR1	0.5218	More...
Q5QGS0	Neurite extension and migration factor	DEG_APCC_KENBOX_2	23:27	VKEND	APC,CDC20,FZR1	0.8948	More...
Q6P587	Acylpyruvase FAHD1, mitochondrial	DEG_APCC_KENBOX_2	199:203	VKEND	APC,CDC20,FZR1	0.6039	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons