DegronMD

Uniprot ID: Q6P587

Source protein: Acylpyruvase FAHD1, mitochondrial

Source gene: FAHD1

Class: DEG_APCC_KENBOX_2

Location: 199:203

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6039

ASA_SCORE: 67.62

COIL: 0.8488

CONS_SCORE: 0.7014

DSS_SCORE: 0.4498

HELIX: 0.0064

FCONS_SCORE: 1.0101

RIG_SCORE: 0.768

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L189F	TCGA-43-8118	LUSC	TCGA	VKEND	DEG_APCC_KENBOX_2	0.0556
p.L189F	DO45471	LUSC	ICGC	VKEND	DEG_APCC_KENBOX_2	0.0556
p.L189V	DO228197	LICA	ICGC	VKEND	DEG_APCC_KENBOX_2	0.0556
p.P213T	DO32297	OV	ICGC	VKEND	DEG_APCC_KENBOX_2	0.0556
p.G211W	SIDM01088	Endometrial Carcinoma	GDSC	VKEND	DEG_APCC_KENBOX_2	0.1111
p.G211W	RL95-2	endometrium	COSMIC	VKEND	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46778	60S ribosomal protein L21	DEG_APCC_KENBOX_2	109:113	VKEND	APC,CDC20,FZR1	0.5218	More...
Q5QGS0	Neurite extension and migration factor	DEG_APCC_KENBOX_2	23:27	VKEND	APC,CDC20,FZR1	0.8948	More...
Q6P587	Acylpyruvase FAHD1, mitochondrial	DEG_APCC_KENBOX_2	199:203	VKEND	APC,CDC20,FZR1	0.6039	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons