DegronMD - P46939(UTRN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K679R	TCGA-55-8097	LUAD	TCGA	KRQIHVD	LIG_APCC_ABBAyCdc20_2	679:685	Mutation altering degron motif	0.6126
p.K679R	DO25699	LUAD	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	679:685	Mutation altering degron motif	0.6126
p.K678N	TCGA-D1-A103	UCEC	TCGA	KRQIHVD	LIG_APCC_ABBAyCdc20_2	679:685	Mutation rewiring degron network	0.3056
p.K678N	DO42312	UCEC	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	679:685	Mutation rewiring degron network	0.3056
p.E670K	TCGA-UY-A9PB	BLCA	TCGA	KRQIHVD	LIG_APCC_ABBAyCdc20_2	679:685	Mutation rewiring degron network	0.0833
p.E670K	DO219041	BLCA	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	679:685	Mutation rewiring degron network	0.0833
p.S694L	DO48576	BLCA	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	679:685	Mutation rewiring degron network	0.0833
p.K689T	DO234373	ESAD	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	679:685	Mutation substituting flanking lysine	0.3333
p.Y671H	DO231937	LICA	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	679:685	Mutation rewiring degron network	0.1111
p.K691N	DO228934	LICA	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	679:685	Mutation substituting flanking lysine	0.2778
p.R693M	DO228952	LICA	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	679:685	Mutation rewiring degron network	0.1111
p.R693M	DO229031	LICA	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	679:685	Mutation rewiring degron network	0.1111
p.C672F	DO228971	LICA	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	679:685	Mutation rewiring degron network	0.1389
p.V687L	DO228986	LICA	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	679:685	Mutation rewiring degron network	0.2778
p.R680I	DO229034	LICA	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	679:685	Mutation altering degron motif	0.6991
p.A694S	DO229006	LICA	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	679:685	Mutation rewiring degron network	0.0833
p.E687A	DO46503	OV	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	679:685	Mutation rewiring degron network	0.2778
p.R682L	DO37651	SKCM	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	679:685	Mutation altering degron motif	0.8428
p.V681A	DO42023	UCEC	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	679:685	Mutation altering degron motif	0.6936
p.K679N	SIDM00524	Small Cell Lung Carcinoma	GDSC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	679:685	Mutation altering degron motif	0.6918
p.K679N	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	679:685	Mutation altering degron motif	0.6918
p.V681I	TUR	haematopoietic and lymphoid tissue	COSMIC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	679:685	Mutation altering degron motif	0.7076

Kaplan plot for UTRN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UTRN

UniProt ID: P46939

Entrez ID: 7402

Protein name: Utrophin (Dystrophin-related protein 1) (DRP-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UTRN in