DegronMD

Uniprot ID: P46939

Source protein: Utrophin

Source gene: UTRN

Class: LIG_APCC_ABBAyCdc20_2

Location: 679:685

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9855

ASA_SCORE: 88

COIL: 0.2453

CONS_SCORE: 0.4786

DSS_SCORE: 0.6031

HELIX: 0.7346

FCONS_SCORE: 1.182

RIG_SCORE: 0.7524

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K679R	TCGA-55-8097	LUAD	TCGA	KRQIHVD	LIG_APCC_ABBAyCdc20_2	0.6126
p.K679R	DO25699	LUAD	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	0.6126
p.K678N	TCGA-D1-A103	UCEC	TCGA	KRQIHVD	LIG_APCC_ABBAyCdc20_2	0.3056
p.K678N	DO42312	UCEC	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E670K	TCGA-UY-A9PB	BLCA	TCGA	KRQIHVD	LIG_APCC_ABBAyCdc20_2	0.0833
p.E670K	DO219041	BLCA	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	0.0833
p.S694L	DO48576	BLCA	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	0.0833
p.K689T	DO234373	ESAD	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	0.3333
p.Y671H	DO231937	LICA	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	0.1111
p.K691N	DO228934	LICA	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R693M	DO228952	LICA	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	0.1111
p.R693M	DO229031	LICA	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	0.1111
p.C672F	DO228971	LICA	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	0.1389
p.V687L	DO228986	LICA	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R680I	DO229034	LICA	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	0.6991
p.A694S	DO229006	LICA	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	0.0833
p.E687A	DO46503	OV	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R682L	DO37651	SKCM	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	0.8428
p.V681A	DO42023	UCEC	ICGC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	0.6936
p.K679N	SIDM00524	Small Cell Lung Carcinoma	GDSC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	0.6918
p.K679N	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	0.6918
p.V681I	TUR	haematopoietic_and_lymphoid_tissue	COSMIC	KRQIHVD	LIG_APCC_ABBAyCdc20_2	0.7076

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46939	Utrophin	LIG_APCC_ABBAyCdc20_2	679:685	KRQIHVD	APC,CDC20,FZR1	0.9855	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons