DegronMD - P47972(NPTX2)

NPTX2

UniProt ID: P47972

Entrez ID: 4885

Protein name: Neuronal pentraxin-2 (NP2) (Neuronal pentraxin II) (NP-II)

External links: UniprotKB HGNC RefSeq COSMIC

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GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V359M	TCGA-2W-A8YY	CESC	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.1111
p.V359M	DO223732	CESC	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.1111
p.H342N	TCGA-55-6985	LUAD	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation altering degron motif	0.6312
p.H342N	DO25659	LUAD	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation altering degron motif	0.6312
p.E336D	TCGA-85-8666	LUSC	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.2778
p.E336D	DO45547	LUSC	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.2778
p.G335W	TCGA-BR-7716	STAD	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.25
p.G335W	DO38675	STAD	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.25
p.E330D	TCGA-CA-6717	COAD	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.1111
p.E330D	DO8264	COAD	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.1111
p.G329R	TCGA-CM-6162	COAD	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.0833
p.G329R	TCGA-D5-6530	COAD	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.0833
p.G329R	DO8479	COAD	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.0833
p.G329R	DO8312	COAD	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.0833
p.G329R	ACH-002005	Skin Cancer	CCLE	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.0833
p.I344M	TCGA-CV-6961	HNSC	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation altering degron motif	0.6507
p.I344M	DO14566	HNSC	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation altering degron motif	0.6507
p.G329E	TCGA-CV-7422	HNSC	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.0833
p.G329E	DO14447	HNSC	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.0833
p.P346S	TCGA-DU-6392	LGG	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation altering degron motif	0.5641
p.P346S	DO22237	LGG	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation altering degron motif	0.5641
p.L332M	TCGA-DX-AB2P	SARC	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.1667
p.L332M	DO220085	SARC	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.1667
p.G335E	TCGA-EE-A2M5	SKCM	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.25
p.G335E	DO222423	MELA	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.25
p.G335E	DO37425	SKCM	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.25
p.E336K	TCGA-FS-A1ZZ	SKCM	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.2778
p.E336K	DO37412	SKCM	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.2778
p.G333D	TCGA-G4-6588	COAD	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.1944
p.G333D	TCGA-LN-A4A2	ESCA	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.1944
p.G333D	DO10140	COAD	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.1944
p.E330K	DO222578	MELA	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.1111
p.V349M	DO28233	OV	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation altering degron motif	0.6097
p.I351T	SIDM01090	Colorectal Carcinoma	GDSC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation altering degron motif	0.7078
p.I351T	ACH-000943	Colon/Colorectal Cancer	CCLE	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation altering degron motif	0.7078
p.I351T	RKO	large intestine	COSMIC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation altering degron motif	0.7078
p.G360E	ACH-000520	Ovarian Cancer	CCLE	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	338:351	Mutation rewiring degron network	0.0833

Kaplan plot for NPTX2 in

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*NOTE: the Kaplan plots were collected from OncoLnc