DegronMD

Uniprot ID: P47972

Source protein: Neuronal pentraxin-2

Source gene: NPTX2

Class: DEG_ODPH_VHL_1

Location: 338:351

E3 ligase: VHL

DEGRON score: 0.5503

ASA_SCORE: 46.3929

COIL: 0.5773

CONS_SCORE: 0.8433

DSS_SCORE: 0.4281

HELIX: 0.0085

FCONS_SCORE: 1.0362

RIG_SCORE: 0.775

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V359M	TCGA-2W-A8YY	CESC	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.1111
p.V359M	DO223732	CESC	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.1111
p.H342N	TCGA-55-6985	LUAD	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.6312
p.H342N	DO25659	LUAD	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.6312
p.E336D	TCGA-85-8666	LUSC	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.2778
p.E336D	DO45547	LUSC	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.2778
p.G335W	TCGA-BR-7716	STAD	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.25
p.G335W	DO38675	STAD	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.25
p.E330D	TCGA-CA-6717	COAD	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.1111
p.E330D	DO8264	COAD	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.1111
p.G329R	TCGA-CM-6162	COAD	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.0833
p.G329R	TCGA-D5-6530	COAD	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.0833
p.G329R	DO8479	COAD	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.0833
p.G329R	DO8312	COAD	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.0833
p.G329R	ACH-002005	Skin Cancer	CCLE	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.0833
p.I344M	TCGA-CV-6961	HNSC	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.6507
p.I344M	DO14566	HNSC	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.6507
p.G329E	TCGA-CV-7422	HNSC	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.0833
p.G329E	DO14447	HNSC	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.0833
p.P346S	TCGA-DU-6392	LGG	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.5641
p.P346S	DO22237	LGG	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.5641
p.L332M	TCGA-DX-AB2P	SARC	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.1667
p.L332M	DO220085	SARC	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.1667
p.G335E	TCGA-EE-A2M5	SKCM	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.25
p.G335E	DO222423	MELA	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.25
p.G335E	DO37425	SKCM	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.25
p.E336K	TCGA-FS-A1ZZ	SKCM	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.2778
p.E336K	DO37412	SKCM	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.2778
p.G333D	TCGA-G4-6588	COAD	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.1944
p.G333D	TCGA-LN-A4A2	ESCA	TCGA	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.1944
p.G333D	DO10140	COAD	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.1944
p.E330K	DO222578	MELA	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.1111
p.V349M	DO28233	OV	ICGC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.6097
p.I351T	SIDM01090	Colorectal Carcinoma	GDSC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.7078
p.I351T	ACH-000943	Colon/Colorectal Cancer	CCLE	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.7078
p.I351T	RKO	large_intestine	COSMIC	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.7078
p.G360E	ACH-000520	Ovarian Cancer	CCLE	LAPWHPIKPGGVLI	DEG_ODPH_VHL_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPWHPIKPGGVLI

Degron related mutations and impact score

Drug responses associated with NPTX2 mutations

All proteins holding degron of LAPWHPIKPGGVLI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P47972	Neuronal pentraxin-2	DEG_ODPH_VHL_1	338:351	LAPWHPIKPGGVLI	VHL	0.5503	More...